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KAKEN_15H03123seika.pdf
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情動を制御するBDNFの直接効果の解明
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Kana |
ジョウドウ オ セイギョスル BDNF ノ チョクセツ コウカ ノ カイメイ
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Jōdō o seigyosuru BDNF no chokusetsu kōka no kaimei
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Regulatory role of BDNF on emotional and cognitive function
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田中, 謙二
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タナカ, ケンジ
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Tanaka, Kenji
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慶應義塾大学・医学部 (信濃町) ・准教授
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Research team head
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科研費研究者番号 : 30329700
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鈴木, 暢
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スズキ, トオル
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Suzuki, Tōru
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Collaborator
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2019
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科学研究費補助金研究成果報告書
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2018
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脳由来神経栄養因子 (BDNF) の発現が増えること・減ることが気分を変化させ、精神疾患発症に関与すると考えられていた。本研究では、この仮説を実験動物個体で証明することに取り組んだ。BDNFの発現を時期特異的、脳領域特異的に増やす・減らす介入を行った。ストレス負荷が無いと考えられる通常飼育では、いかなる介入も情動・認知に影響を与えなかった。涙の基礎分泌を自律神経応答の指標として、ストレス負荷からの回復過程を調べたところ、BDNFの発現低下は、ストレスからの回復を遅くさせた。このことから、BDNFは健康な状態よりもむしろストレスが負荷された状態において、機能を発揮する分子であると推測された。
It is well accepted that brain-derived neurotrophic factor (BDNF) is involved in the synaptic plasticity. Human studies demonstrated that serum BDNF amount can be used as a biomarker of neuropsychiatric conditions. However, how BDNF directly regulates brain higher functions is still unknown. Here we developed BDNF gene modifying mice in which BDNF gene expression was capable of time- and region-dependent manipulation. In the stress-free condition, up- or down-regulation of BDNF gene expression did not cause any anxiety-like and depression-like behaviors.In the stressful condition, down-regulation of BDNF gene expression impaired the autonomic function characterized with basal tear secretion. In particular, down-regulation of BDNF expression delayed a recovery from the stress. We conclude that levels of BDNF expression affect the stress resilience in stressful condition but not in stress free condition.
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研究種目 : 基盤研究 (B) (一般)
研究期間 : 2015~2018
課題番号 : 15H03123
研究分野 : 神経化学
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