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Title |
Title |
トウダイグサ有毒ジテルペン、ユーホルニンの合成研究
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Kana |
トウダイグサ ユウドク ジテルペン ユーホルニン ノ ゴウセイ ケンキュウ
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Romanization |
Todaigusa yudoku jiterupen yuhorunin no gosei kenkyu
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Other Title |
Title |
Synthetic study on euphornin, a toxic diterpene from "Euphorbia helioscopia" L.
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Romanization |
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Creator |
Name |
小瀬村, 誠治
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Kana |
コセムラ, セイジ
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Romanization |
Kosemura, Seiji
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Affiliation |
慶応義塾大学法学部日吉化学教室
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Affiliation (Translated) |
Department of Chemistry,Hiyoshi Campus Keio University
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Name |
栗原, 伸和
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Kana |
クリハラ, シンワ
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Romanization |
Kurihara, Shinwa
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Affiliation |
慶応義塾大学理工学部化学科
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Affiliation (Translated) |
Department of Chemistry, Faculty of Science and Technology, Keio University
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Link |
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Name |
山村, 庄亮
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Kana |
ヤマムラ, ショウスケ
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Romanization |
Yamamura, Shosuke
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Affiliation |
慶応義塾大学理工学部化学科
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Affiliation (Translated) |
Department of Chemistry,Faculty of Science and Technology, Keio University,
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Publisher |
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慶應義塾大学日吉紀要刊行委員会
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Kana |
ケイオウ ギジュク ダイガク ヒヨシ キヨウ カンコウ イインカイ
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Romanization |
Keio gijuku daigaku hiyoshi kiyo kanko iinkai
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2002
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Physical description |
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Source Title |
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慶應義塾大学日吉紀要. 自然科学
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Volume |
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Issue |
32
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Year |
2002
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Month |
11
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Start page |
39
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End page |
54
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Abstract |
Euphornin, isolated from Euphorbia helioscopia L.(Toudai Gusa in Japanese), isatoxic diterpene having antitumor activity. Euphornin is a highly oxygenatedditerpene containing two double bond included in a 12-membered ring. Oxidativecleavage of both double bonds afforded two segments, the C1-C5・C12-Cl5 segmentand the C6-C11 segment, which would be key intermediates for total synthesis ofeuphornin. The C1-C5・C12-C15 segment is a five membered ring compound includ-ing four asymmetric carbons on the ring and two on the side chain. And the C1-C5・C12-C15 segment equivalent to these of the nature diterpene has been synthes-ized from commercially available L-malic acid in our synthetic studies. In thepresent paper, the degradation reaction of euphornin has been carried out to affordthe C1-C5・C12-C15 segment which is expected to be coupled with the C6-C11segment giving rise to euphornin.
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Departmental Bulletin Paper
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History |
May 14, 2007 | | フリーキーワード, プレビュー, 本文, キーワード を変更 |
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