We are in the middle of a major technological revolution that is transforming our ways of producing, consuming, organizing, living, and dying. Cities and Regions are also changing under the impact of new technologies. Moreover, the revolution of information technologies is transforming the material forms of social organization, including both spatial forms and processes. This paper aims at exploring the new types of spatial form and process under the condition of the new technological paradigm, that is, "the informational mode of development", which is the key concept of the Regulation School. The discussion will show "the Quasi-Integration Verticale" as a new social division of labor and "the Space of Flows" which is the new spatial experience of daily life.