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AN00069296-20070900-0165.pdf
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Title |
Title |
活性酸素のp38MAPKを介する造血幹細胞寿命制御
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Kana |
カッセイ サンソ ノ p38MAPK オ カイスル ゾウケツ カンサイボウ ジュミョウ セイギョ
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Romanization |
kassei sanso no p38MAPK o kaisuru zoketsu kansaibo jumyo seigyo
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Other Title |
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Creator |
Name |
伊藤, 圭介
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Kana |
イトウ, ケイスケ
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Romanization |
Ito, Keisuke
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Affiliation |
慶慮義塾大学医学部発生分化生物学
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Name |
平尾, 敦
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Kana |
ヒラオ, アツシ
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Romanization |
Hirao, Atsushi
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Affiliation |
スローンケタリング記念癌センター癌生物学・遺伝学教室
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Affiliation (Translated) |
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Name |
須田, 年生
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Kana |
スダ, トシオ
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Romanization |
Suda, Toshio
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Affiliation |
金沢大学がん研究所腫瘍分子科学研究部門遺伝子・染色体構築研究分野
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Name |
慶應医学会
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Kana |
ケイオウ イガッカイ
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Romanization |
Keio igakkai
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Date |
Issued (from:yyyy) |
2007
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Issued (to:yyyy) |
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Created (yyyy-mm-dd) |
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Updated (yyyy-mm-dd) |
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Physical description |
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Source Title |
Name |
慶應医学
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Name (Translated) |
Journal of the Keio Medical Society
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Volume |
84
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Issue |
3
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Year |
2007
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Month |
9
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Start page |
165
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End page |
168
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Abstract |
Hematopoie1ic stem cells(HSCs)are able to self-renew and to differentiate along all hematopoietic lineagesthroughout the entire life-timc of organlsm. Appropriate control of HSC self-renewal is crucial for the mainte-nance of hematopoietic homeostasis. Here we show that activation of p38MAPK in response to increasing!evels of reactive oxygen species (ROS) Iimits the lifespan of HSCs in vivo, In Atm (-/-) mice, elevation of ROSlevels induces HSC-specific phosphorylation of p38MAPK accompanied by a defect in the maintenance of HSCquiescence. lnhibition of p38MAPK rescued ROS-induced defects in HSC repopulating capacity and in themaintenance of HSC quiescence, indicating that the ROS-p38MAPK pathway contributes to exhaustion of thestem cell population. Furthermore, prolonged treatment with an antioxidant or an inhibitor of p38MAPK ex・tended the lifespan of HSCs from wild・type mice in serial transplantation experiments. These data show thatinactivation of p38MAPK protects HSCs against loss of self-rcnewal capacity.
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