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AN00069296-20060300-0029.pdf
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:application/pdf |
Download
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:1.8 MB
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| Last updated |
:Mar 11, 2009 |
| Downloads |
: 1134 |
Total downloads since Mar 11, 2009 : 1134
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| Title |
| Title |
神経病原性レトロウイルスA8-Vのenv遺伝子発現に見られた奇妙なスプライシング
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| Kana |
シンケイ ビョウゲンセイ レトロウイルス Ａ８ － Ｖ ノ ｅｎｖ イデンシ ハツゲン ニ ミラレタ キミョウナ スプライシング
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shinkei byogensei retoroirusu A8 - V no env idenshi hatsugen ni mirareta kimyona supuraishingu
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Eccentric splicing found in env gene expression of neuropathogenic A8-V
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渡辺, 里仁
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ワタナベ, リヒト
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Watanabe, Rihito
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| Affiliation |
創価大学工学部生命情報工学科
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| Affiliation (Translated) |
Department of Bioinformatics Faculty of Engineering, Soka University, Tangi-cho 1-236, Hachioji, Tokyo
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高瀬(余田), 明
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タカセ （ヨデン）, サヤカ
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Takase (Yoden), Sayaka
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| Affiliation |
創価大学工学部生命情報工学科
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| Affiliation (Translated) |
Department of Bioinformatics Faculty of Engineering, Soka University, Tangi-cho 1-236, Hachioji, Tokyo
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山川, 圭
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ヤマカワ, ケイ
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Yamakawa, Kei
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| Affiliation |
創価大学工学部生命情報工学科
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| Affiliation (Translated) |
Department of Bioinformatics Faculty of Engineering, Soka University, Tangi-cho 1-236, Hachioji, Tokyo
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池田, 富夫
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イケダ, トミオ
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Ikeda, Tomio
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| Affiliation |
デンカ生研株式会社
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| Affiliation (Translated) |
Denka Seiken Co., LTD.1-2-2 Minami Honcho, Gosen-shi, Niigata
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慶應医学会
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| Kana |
ケイオウ イガッカイ
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Keio igakkai
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2006
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慶應医学
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Journal of the Keio Medical Society
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| Volume |
83
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1
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2006
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3
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| Start page |
29
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| End page |
35
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| Abstract |
Packaging cell lines PacNIH/A8β and PacNIH/A8δ, which were introduced by the DNA of expression vectors pA8(Ψ-)βand pA8(Ψ-)δ ｒe spective1y, to produce pseud-retroviral particles in the retroviral vector system, were established. Both the expression vectors were constructed using the genes of A8-V, which is an isolate from Friend murine leukemia virus(F-MLV) and shows higher proliferation rates in the central nervous system(CNS) of rats and mice compared with original F-MLV. These two expression vectors utilize a different polyadenylation signal (polyA signal) for the expression of retroviral genes. The former employs a 0.85kb fragment in the SV40 early region as a polyA signal, and the latter, a 0.13kb of the same
region. PacNIH/A8β showed an unstable expression of the env gene in the A8-V genome, whereas all of the retroviral gene expressions in the PacNIH/A8δ were perfect. An occurrence of abnormal splicing in the mRNA for the env gene in the PacNIH/A8β cells was suggested.
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