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AN00069296-20041200-0295.pdf
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Title |
Title |
高血糖が腎糸球体血行動態に与える影響の検討
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Kana |
コウケットウ ガ ジンシキュウタイ ケッコウ ドウタイ ニ アタエル エイキョウ ノ ケントウ
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Romanization |
koketto ga jinshikyutai kekko dotai ni ataeru eikyo no kento
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Other Title |
Title |
Effect of hyperglycemia in renal glomerular hemodynamics
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Creator |
Name |
本間, 康一郎
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Kana |
ホンマ, コウイチロウ
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Romanization |
Honma, Koichiro
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Affiliation |
慶應義塾大学医学部内科学教室
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Affiliation (Translated) |
Department of Internal Medicine, School of Medicine, Keio University
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Name |
猿田, 享男
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Kana |
サルタ, イクオ
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Romanization |
Saruta, Ikuo
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Name |
慶應医学会
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Kana |
ケイオウ イガッカイ
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Romanization |
Keio igakkai
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Date |
Issued (from:yyyy) |
2004
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Created (yyyy-mm-dd) |
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Physical description |
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Source Title |
Name |
慶應医学
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Name (Translated) |
Journal of the Keio Medical Society
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Volume |
81
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Issue |
4
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Year |
2004
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Month |
12
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Start page |
295
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End page |
308
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Abstract |
Elevated renal perfusion pressure (RPP) elicits constriction of renal afferent arterioles (AFF), which comprises two mechanisms, myogenic response and tubuloglomerular feedback (TGF). This study examined whether pressure-induced AFF constriction was impaired in acute and chronic hyperglycemia. Intravital CCD camera was used to visualize the renal microcirculation. In normoglycemic rats, elevated RPP caused 17.5±2.0% AFF constriction. Acute hyperglycemia by infusion of high glucose solution elicited AFF vasodilation, and blunted the pressure-induced constriction(一8.7±1.0%). In contrast, the same elevation in plasma osmolality with mannitol failed to alter the basal diameter or the pressure-induced constriction of AFF. In acute hyperglycemic rats, both gadolinium (a myogenic response inhibitor)and furosemide la TGF inhibitor) inhibited the pressure-induced AFF constriction. During the inhibition of myogenic tone by gadolinium, the inhibition of nNOS by S-methyl-L-thiocitrulline (L-SMTC) restored the acute hyperglycemis-induced impaired AFF constriction, but this ameliorating action was absentduring the TGF inhibition by furosemide, suggesting selective activity of nNOS-associated NO on TGF. Similarly, in chronic hyperglycemic (Zucker obese) rats, myogenic response and TGF were blunted, and L-SMTC ameliorated the blunted TGF response. In conclusion, hyperglycemia causes impaired pressure response in both acute and chronic hyperglycemia. The blunted response is attributed to impairment in myogenic and TGF-mediated AFF constriction; the latter effect is caused by enhanced activity of nNOS.
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Keyword |
tubul oglomerular feedback(TGF)
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