We investigated the effect on six decocted Chinese herbal medicines, Seihi-to. Seihi-to with minor change (Seihi-to-kagen), Shoutu-san, Shoufu-san plus large amount of calcium sulfate. Huang's experienced regimen, and Huang's regimen with minor change in thirty patients suffered from adult-type atopic-dermatitis (AD), which is severe skin lesion spread on whole surface of the body. One adequate Chinese herbal medicine was selected by Oriental Medicine based analysis method for each patient. We chose the AD score to estimate the effect of each Chinese herbal medicine, The AD scores were recorded everyday by each pabent and the AD scores before administration of Chinese herbal medicine and those of after administration were compared respectively. The AD scores reduced to below one-second within six months in 6 out of 11 cases(54.5%) with the treatment of Seihi-to, in 6 out of 6(100%) with Seihi-to-kagen, in 1 out of 2 (50%) with Shoufu-san, in 10 out of 14(71.4%)with Shoutu-san plus, in l out of l (100%)with Huang's regimen and in 8 out of 9(88.9%)with Huang's changed regimen. Finally, skin lesions of 26 out of 28 cases(92.9%)were significantly improved and the dosage of steroid significantly decreased in twenty seven cases(96.4%).Those findings suggested that the adequate Chinese herbal medicines by Oriental Medicine based analysis method might be positively useful as a combination medicine with steroid ointment for anti-severe, hard-to-cured AD.

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