Item Type |
Article |
ID |
|
Preview |
Image |
|
Caption |
|
|
Full text |
KAKEN_26861467seika.pdf
Type |
:application/pdf |
Download
|
Size |
:208.0 KB
|
Last updated |
:Apr 22, 2024 |
Downloads |
: 548 |
Total downloads since Apr 22, 2024 : 548
|
|
Release Date |
|
Title |
Title |
mTOR signaling・紫外線・抗酸化剤に着目した近視進行抑制効果の比較
|
Kana |
mTOR signaling・シガイセン・コウサンカザイ ニ チャクモクシタ キンシ シンコウ ヨクセイ コウカ ノ ヒカク
|
Romanization |
mTOR signaling shigaisen kōsankazai ni chakumokushita kinshi shinkō yokusei kōka no hikaku
|
|
Other Title |
Title |
Comparison of suppression effect of myopia progression focusing on mTOR signaling, ultraviolet light, and antioxidant
|
Kana |
|
Romanization |
|
|
Creator |
Name |
鳥居, 秀成
|
Kana |
トリイ, ヒデマサ
|
Romanization |
Torii, Hidemasa
|
Affiliation |
慶應義塾大学・医学部・特任助教
|
Affiliation (Translated) |
|
Role |
Research team head
|
Link |
科研費研究者番号 : 50445326
|
Name |
栗原, 俊英
|
Kana |
クリハラ, トシヒデ
|
Romanization |
Kurihara, Toshihide
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
世古, 裕子
|
Kana |
セコ, ユウコ
|
Romanization |
Seko, Yūko
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
根岸, 一乃
|
Kana |
ネギシ, カズノ
|
Romanization |
Negishi, Kazuno
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
大沼, 一彦
|
Kana |
オオヌマ, カズヒコ
|
Romanization |
Ōnuma, Kazuhiko
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
稲葉, 隆明
|
Kana |
イナバ, タカアキ
|
Romanization |
Inaba, Takaaki
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
川島, 素子
|
Kana |
カワシマ, モトコ
|
Romanization |
Kawashima, Motoko
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
姜, 効炎
|
Kana |
|
Romanization |
Jiang, Xiaoyan
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
近藤, 眞一郎
|
Kana |
コンドウ, シンイチロウ
|
Romanization |
Kondō, Shin'ichirō
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
宮内, 真紀
|
Kana |
ミヤウチ, マキ
|
Romanization |
Miyauchi, Maki
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
三輪, 幸裕
|
Kana |
ミワ, ユキヒロ
|
Romanization |
Miwa, Yukihiro
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
堅田, 侑作
|
Kana |
カタダ, ユウサク
|
Romanization |
Katada, Yūsaku
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
森, 紀和子
|
Kana |
モリ, キワコ
|
Romanization |
Mori, Kiwako
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
加藤, 圭一
|
Kana |
カトウ, ケイイチ
|
Romanization |
Katō, Keiichi
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
坪田, 欣也
|
Kana |
ツボタ, キンヤ
|
Romanization |
Tsubota, Kin'ya
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
後藤, 浩
|
Kana |
ゴトウ, ヒロシ
|
Romanization |
Gotō, Hiroshi
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
小田, 真由美
|
Kana |
オダ, マユミ
|
Romanization |
Oda, Mayumi
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
羽鳥, 恵
|
Kana |
ハトリ, メグミ
|
Romanization |
Hatori, Megumi
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
坪田, 一男
|
Kana |
ツボタ, カズオ
|
Romanization |
Tsubota, Kazuo
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
|
Edition |
|
Place |
|
Publisher |
|
Date |
Issued (from:yyyy) |
2017
|
Issued (to:yyyy) |
|
Created (yyyy-mm-dd) |
|
Updated (yyyy-mm-dd) |
|
Captured (yyyy-mm-dd) |
|
|
Physical description |
|
Source Title |
Name |
科学研究費補助金研究成果報告書
|
Name (Translated) |
|
Volume |
|
Issue |
|
Year |
2016
|
Month |
|
Start page |
|
End page |
|
|
ISSN |
|
ISBN |
|
DOI |
|
URI |
|
JaLCDOI |
|
NII Article ID |
|
Ichushi ID |
|
Other ID |
|
Doctoral dissertation |
Dissertation Number |
|
Date of granted |
|
Degree name |
|
Degree grantor |
|
|
Abstract |
我々は屋外環境に豊富にある360-400 nmの光(バイオレット光, 以下VL)に着目し, VLを浴びたヒヨコの近視進行が抑制され, VLを浴びたヒヨコの目でEGR1が上昇していることを発見した。また臨床研究において, VLを透過するコンタクトレンズを装用している人の方が, VLを透過しないコンタクトレンズや眼鏡を装用している人よりも眼軸長伸長量が少なかった。さらに現在我々が使用しているLEDや蛍光灯などの照明にはVLはほとんど含まれておらず, 眼鏡やガラスなどの材質もVLをほとんど通さないことがわかった。即ち現代社会においてはVLが欠如しており, これが近視の世界的な増大と関係している可能性がある。
We focused on violet light (VL, 360~400 nm wavelength), which is abundant in outdoor environments, and carried out research using a chick myopia model. Through that model, myopic progression of chicks exposed to VL was suppressed, and early growth response 1 (EGR1) was confirmed to be upregulated in chicks exposed to VL. In addition, the research also suggests that those wearing contact lenses that transmit VL suppress myopia progression more than those wearing contact lenses or glasses that do not transmit VL, suggesting that myopia progresses when wearing glasses that do not transmit VL. Furthermore, the LEDs and fluorescent lamps often used today contain little VL, and it was found that VL does not pass through materials such as the UV-protected eyeglasses and window glass. That is, in modern society there is a lack of VL, which may be related to the global increase in myopia.
|
|
Table of contents |
|
Keyword |
|
NDC |
|
Note |
研究種目 : 若手研究(B)
研究期間 : 2014~2016
課題番号 : 26861467
研究分野 : 近視
|
|
Language |
|
Type of resource |
|
Genre |
|
Text version |
|
Related DOI |
|
Access conditions |
|
Last modified date |
|
Creation date |
|
Registerd by |
|
History |
Jul 29, 2019 | | 著者 を変更 |
Aug 27, 2019 | | タイトル ローマ字,上位タイトル 名前,博士論文情報 学位授与番号 を変更 |
Apr 22, 2024 | | Creator を変更 |
|
|
Index |
|
Related to |
|