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KAKEN_26861414seika.pdf
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Download
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:130.3 KB
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| Last updated |
:Sep 21, 2017 |
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: 166 |
Total downloads since Sep 21, 2017 : 166
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| Title |
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マウスを用いた加齢性耳鳴の検討
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| Kana |
マウス オ モチイタ カレイセイ ミミナリ ノ ケントウ
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Mausu o mochiita kareisei miminari no kento
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Tinnitus in aging model mice
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大石, 直樹
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オオイシ, ナオキ
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Oishi, Naoki
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| Affiliation |
慶應義塾大学・医学部・専任講師
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Research team head
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科研費研究者番号 : 10348740
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2017
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科学研究費補助金研究成果報告書
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2016
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CBA/Jマウスにおける加齢性難聴に付随する耳鳴をGap Detection Test(以下GDT)によって評価した。同一検体を用いて緩徐な加齢性難聴に伴う耳鳴の評価を経時的に行った。CBA/Jマウスを生後9ヶ月から20ヶ月まで経過観察し, 聴力低下は認められた上で24kHzにgapによる予告刺激の抑制度合いに有意差が生じた。つまり, 24kHzの耳鳴が検出された。今後はより大規模で均一な実験系で耳鳴の一定な評価を得ることで, 急性難聴モデルと慢性難聴モデルでの耳鳴発生の差異を明らかにし, 耳鳴の治療などにつながっていくことが期待される。
Tinnitus in aging model mice was evaluated by gap detection test (GDT). Tinnitus accompanied by presbycusis was accessed prospectively and individually in CBA/J mice. The hearing level and GDT were measured periodically from the age of 9 months to 20 months. The hearing level deteriorated according to their age and tinnitus at 24 kHz was detected by GDT at the age of 20 months. These results are expected to lead to the finding of therapy on tinnitus followed by chronic hearing loss such as aging.
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研究種目 : 若手研究(B)
研究期間 : 2014～2016
課題番号 : 26861414
研究分野 : 耳科学
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