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KAKEN_26860149seika.pdf
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Download
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:162.1 KB
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| Last updated |
:Jan 6, 2017 |
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Total downloads since Jan 6, 2017 : 833
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| Title |
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水晶体細胞膜のチャネル及び細胞接着の役割を担うアクアポリン0の機能制御機構の解明
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スイショウタイ サイボウマク ノ チャネル オヨビ サイボウ セッチャク ノ ヤクワリ オ ニナウ アクアポリン0 ノ キノウ セイギョ キコウ ノ カイメイ
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Suishotai saibomaku no chaneru oyobi saibo setchaku no yakuwari o ninau akuaporin0 no kino seigyo kiko no kaimei
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Study of Rules and Functions with Aquaporin 0
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中澤, 洋介
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ナカザワ, ヨウスケ
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Nakazawa, Yosuke
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| Affiliation |
慶應義塾大学・薬学部・助教
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Research team head
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科研費研究者番号 : 60411708
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2016
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科学研究費補助金研究成果報告書
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2015
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本研究では, 水晶体特異的な水チャネルであるアクアポリン0(AQP0) の物質透過能および, 細胞接着能について検討した。その結果, (1) AQP0は水だけではなくアスコルビン酸を透過することが明らかとなり, (2) AQP1発現L細胞では認めれれなかった細胞接着が, AQP0発現L細胞同士の組み合わせでのみ観察された。
(1) The permeation assay of AQP0 was used the stable L-cell line expressing AQP0. As the result, AQP0 can permeate ascorbic acid ex vivo, and also indicate that there is a difference between the import and export of ascorbic acid via AQP0 channel. (2) The cell adhesion assay of AQP0 was revealed that AQP0 could bind directly to the opposing membrane.
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研究種目 : 若手研究(B)
研究期間 : 2014～2015
課題番号 : 26860149
研究分野 : 生物学
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