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KAKEN_26702019seika.pdf
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:Nov 12, 2018 |
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超高速ミー散乱増強光の多光子過程による再生医療用薬剤放出技術の研究
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チョウコウソク ミー サンラン ゾウキョウコウ ノ タコウシ カテイ ニ ヨル サイセイ イリョウヨウ ヤクザイ ホウシュツ ギジュツ ノ ケンキュウ
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Chōkōsoku mī sanran zōkyōkō no takōshi katei ni yoru saisei iryōyō yakuzai hōshutsu gijutsu no kenkyū
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Molecular release for tissue engineering based on ultrafast mie scattered light
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寺川, 光洋
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テラカワ, ミツヒロ
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Terakawa, Mitsuhiro
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慶應義塾大学・理工学部・准教授
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Research team head
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科研費研究者番号 : 60580090
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2018
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科学研究費補助金研究成果報告書
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2017
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本研究では, 再生医療用足場への応用に向け, 超高速ミー散乱増強光を用いて近赤外光照射による薬剤放出制御技術を創出することを目的とした。ゲスト分子内包カプセルの作製, フェムト秒レーザー照射をトリガーとする内包分子放出の実験実証, 生分解性ポリマーの分解速度変化および相互作用物理探索を目的とした分析, 三次元足場を想定した蛍光分子内包カプセルを含有した三次元構造の作製, そして, 三次元構造へのレーザー照射により蛍光分子放出が増大することを実証した。以上より, 生体組織への透過性が高い近赤外光の多光子過程を利用した内包分子放出方法を実現した。
Stimuli-responsible controlled release of molecules was investigated by using near-infrared light toward the realization of efficient scaffold in tissue engineering. The method investigated was based on the ultrafast phenomena of intense Mie scattered light. Fabrication of guest-molecule-embedded capsules, experimental demonstration of femtosecond laser pulse-triggered molecular release, investigation on biodegradability of the polymers, fabrication of 3D structures as well as demonstration of molecular release were carried out. In summary, demonstration of molecular release via multi-photon process of near-infrared light was achieved.
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研究種目 : 若手研究(A)
研究期間 : 2014～2017
課題番号 : 26702019
研究分野 : レーザープロセシング
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