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KAKEN_26670408seika.pdf
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Title |
Title |
iPS細胞を用いたSCVTdP疾患概念の構築と新規治療方法の開発
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Kana |
iPS サイボウ オ モチイタ SCVTdP シッカン ガイネン ノ コウチク ト シンキ チリョウ ホウホウ ノ カイハツ
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Romanization |
iPS saibo o mochiita SCVTdP shikkan gainen no kochiku to shinki chiryo hoho no kaihatsu
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Disease modeling for SCVTdP by iPS cells
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湯浅, 慎介
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Kana |
ユアサ, シンスケ
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Yuasa, Shinsuke
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慶應義塾大学・医学部・講師
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Research team head
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科研費研究者番号 : 90398628
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2016
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科学研究費補助金研究成果報告書
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2015
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Abstract |
SCVTdP患者からiPS細胞を作製した。同iPS細胞とコントロールiPS細胞から心筋細胞を分化誘導, 精製し, 電気生理学的解析, 分子生物学的解析を行った。電気生理学的解析として行った細胞外電位解析, 活動電位解析, パッチクランプによる解析により, 疾患特異的な表現型を同定しえた。詳細な機能解析を続け, 治療方法の開発へ繋げていく。
We generated iPS cells from patients with short coupled variant TdP (SCVTdP). Cardiomyocytes were differentated from control-iPS cells and SCVTdP-iPS cells. Then we performed the electrophysiological analysis using iPS cell-derived cardiomyocytes. We identified the specific phenotype in SCVTdP-iPS cell-derived cardiomyocytes.
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研究種目 : 挑戦的萌芽研究
研究期間 : 2014~2015
課題番号 : 26670408
研究分野 : 循環器内科
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