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KAKEN_26660118seika.pdf
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Title |
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体質改善・疾患予防を目指した腸内エコシステム制御技術の開発
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Kana |
タイシツ カイゼン・シッカン ヨボウ オ メザシタ チョウナイ エコシステム セイギョ ギジュツ ノ カイハツ
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Taishitsu kaizen shikkan yobo o mezashita chonai ekoshisutemu seigyo gijutsu no kaihatsu
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Development of fundamental technology for gut ecosystem regulation towards preventive and therapeutic medicine
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福田, 真嗣
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フクダ, シンジ
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Fukuda, Shinji
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慶應義塾大学・政策・メディア研究科・特任准教授
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Research team head
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科研費研究者番号 : 80435677
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佐々木, えりか
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ササキ, エリカ
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Sasaki, Erika
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公益財団法人実験動物中央研究所・応用発生学研究センター・センター長
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Research team member
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科研費研究者番号 : 70390739
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2016
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科学研究費補助金研究成果報告書
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2015
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われわれの腸管内には, 多種多様な腸内細菌が生息しており, 腸管細胞と密接に相互作用することで複雑な生態系, すなわち「腸内エコシステム」を形成している。腸内エコシステムのバランスの乱れが様々な疾患につながるものの, その分子機構の詳細は不明であったことから本研究では, ヒトへの応用を将来的な目標とし, 霊長類であるコモンマーモセットを用いた腸内エコシステム制御技術の開発を行った。その結果, 抗生物質投与後に正常腸内細菌叢を移植することで, 慢性下痢症の治療効果が得られる可能性が示唆された。
The gut microbiota form a highly complex ecological community together with host intestinal cells. The so-called gut ecosystem has a profound influence on human physiology and pathology. It has been reported that imbalance in the structure of gut ecosystem could be a risk factor in human disorders including not only gut-associated disorders, but also systemic diseases. However, the molecular basis of the function of gut microbiota through host-microbial crosstalk remain obscure. To this end, we tried to development of fundamental technology for gut ecosystem regulation towards preventive and therapeutic medicine using non-human primate, common marmoset, due to the similarity of intestinal environment to human. Our experiments showed that antibiotics treatment followed by healthy fecal microbiota transplantation (FMT) ameliorated chronic diarrhea in common marmoset, suggesting that the antibiotics and FMT combination method might be effective in human patient.
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研究種目 : 挑戦的萌芽研究
研究期間 : 2014~2015
課題番号 : 26660118
研究分野 : 腸内細菌学
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Aug 28, 2023 | | Creator,Abstract 内容,Note 注記 を変更 |
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