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KAKEN_26462668seika.pdf
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Download
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:306.8 KB
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眼慢性移植片対宿主病における老化細胞とドナー間葉系幹細胞の役割と治療法の開発
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ガン マンセイ イショクヘンタイシュクシュビョウ ニ オケル ロウカ サイボウ ト ドナー カンヨウケイ カンサイボウ ノ ヤクワリ ト チリョウホウ ノ カイハツ
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Gan mansei ishokuhentaishukushubyo ni okeru roka saibo to dona kanyokei kansaibo no yakuwari to chiryoho no kaihatsu
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A significant role of senescent cells and donor mesenchymal stem cells in ocular chronic graft-versus-host disease and development of new therapy
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小川, 葉子
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オガワ, ヨウコ
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Ogawa, Yoko
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慶應義塾大学・医学部・特任准教授
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Research team head
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科研費研究者番号 : 30160774
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坪田, 一男
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ツボタ, カズオ
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Tsubota, Kazuo
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慶應義塾大学・医学部・教授
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Research team member
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科研費研究者番号 : 40163878
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榛村, 重人
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シンムラ, シゲト
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Shinmura, Shigeto
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慶應義塾大学・医学部・准教授
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Research team member
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科研費研究者番号 : 00235780
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2017
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科学研究費補助金研究成果報告書
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2016
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| Abstract |
眼移植片対宿主病(GVHD)の線維化にドナー由来新鮮骨髄間葉系幹細胞(MSC)と老化マクロファージが主要な役割を担う事を証明した(Ogawa, Y. eLife, 2016)。眼GVHDでは, ドナーMSCとマクロファージは早期よりGVHD涙腺に浸潤しMSCと相互作用し活性化して老化にかかわる液性因子を分泌することを見出した。組織に浸潤するドナーMSCに免疫原性の高いMHC class II陽性分画が存在し生着することをを確認した。ドナーMSC除去移植または老化関連液性因子の一つのサイトカインに対する中和抗体投与により眼GVHDの病態進展への関連性を検証した。
We found that a significant role of mesenchymal stem cells (MSCs) and senescent macrophages in the pathogenic fibrosis in ocular graft-versus-host disease (GVHD). Donor MSCs and senescent macrophages expressing p16 were infiltrated into lacrimal glands and activated by interacting each other in early onset of ocular GVHD by secreting senescent related factors. We confirmed immunogenic and MHC class II+ MSCs infiltrated into cGVHD target organs especially lacrimal gland. We analysed the effectiveness of depletion of MSCs transplantation or suppression of a senescent associated cytokine in development of fibrosis and inflammation in ocular GVHD.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2014～2016
課題番号 : 26462668
研究分野 : 眼表面免疫応答
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