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KAKEN_26461702seika.pdf
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Title |
Title |
乾燥環境下におけるフィラグリン欠損マウスを用いたアトピー疾患発症機序の解明
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Kana |
カンソウ カンキョウカ ニ オケル フィラグリン ケッソン マウス オ モチイタ アトピー シッカン ハツショウ キジョ ノ カイメイ
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Kanso kankyoka ni okeru firagurin kesson mausu o mochiita atopi shikkan hatsusho kijo no kaimei
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Clarification of the pathogenesis of atopic disease by using filaggrin deficient mice in dry environment
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川崎, 洋
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Kana |
カワサキ, ヒロシ
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Romanization |
Kawasaki, Hiroshi
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Affiliation |
慶應義塾大学・医学部・共同研究員
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Research team head
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科研費研究者番号 : 70445344
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塩濱, 愛子
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シオハマ, アイコ
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Shiohama, Aiko
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慶應義塾大学・医学部・特任助教
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Research team member
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科研費研究者番号 : 40383731
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久保, 亮治
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クボ, アキハル
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Romanization |
Kubo, Akiharu
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慶應義塾大学・医学部・准教授
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Research team member
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科研費研究者番号 : 70335256
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天谷, 雅行
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Kana |
アマガイ, マサユキ
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Romanization |
Amagai, Masayuki
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Affiliation |
慶應義塾大学・医学部・教授
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Research team member
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科研費研究者番号 : 90212563
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2017
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科学研究費補助金研究成果報告書
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2016
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Abstract |
フィラグリン欠損マウスを乾燥環境下で飼育するというモデルを用いて, フィラグリン欠損角層の機能が乾燥環境の影響を受け増悪し, アトピー疾患の発症を導く機序を解明することを目指した。乾燥環境下では通常湿度環境下で飼育したマウスに比べバリア機能の低下と経皮免疫応答の亢進を認め, それはフィラグリン欠損マウスで顕著だった。野生型マウスとフィラグリン欠損マウスの皮膚のトランスクリプトーム解析では, 生後より低湿度環境下で飼育した場合に比べ, 通常湿度環境下で飼育した場合には発現変動遺伝子がほとんど検出されなかった。フィラグリンの機能異常は, 湿度環境因子と密接に関わり表現型の発現に影響する。
We aimed to clarify the pathogenesis that stratum corneum function of filaggrin deficient mice was exacerbated by the dry condition and lead to develop atopic disease, by using the filaggrin deficient mouse model grown in dry environment. Excessive barrier dysfunction and aberrant percutaneous sensitization were evident in the mice kept in dry condition, and these extents were more obvious in filaggrin deficient mice. Skin transcriptomic analysis of differentially expressed genes (DEG) between filaggrin deficient and wild-type mice revealed that very few genes were differentially expressed in normal humidity condition as compared with DEG in dry condition, suggesting that the impact of filaggrin deficiency was not significant in humid condition. Thus, we demonstrated that functional disorder due to filaggrin deficiency had an impact on phenotypic expression of the mice, closely associated with environmental factor of humidity.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2014~2016
課題番号 : 26461702
研究分野 : 医歯薬学
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