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KAKEN_26282211seika.pdf
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自然免疫－獲得免疫を制御する外因性･内因性分子の合成と機能解析、新規制御分子創製
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シゼン メンエキ－カクトク メンエキ オ セイギョスル ガイインセイ・ナイインセイ ブンシ ノ ゴウセイ ト キノウ カイセキ, シンキ セイギョ ブンシ ソウセイ
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Shizen meneki-kakutoku meneki o seigyosuru gaiinsei naiinsei bunshi no gosei to kino kaiseki, shinki seigyo bunshi sosei
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Immunostimulatory endogenous and exogenous compounds : synthesis, functional analysis and development of immunomodulatory designed compounds
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藤本, ゆかり
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フジモト, ユカリ
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Fujimoto, Yukari
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慶應義塾大学・理工学部・教授
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Research team head
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科研費研究者番号 : 00362616
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井貫, 晋輔
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イヌキ, シンスケ
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Inuki, Shinsuke
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慶應義塾大学・理工学部・助教
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Research team member
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科研費研究者番号 : 70736272
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2017
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科学研究費補助金研究成果報告書
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2016
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免疫機構の制御は多くの疾患の理解と治療に繋がることから, その解明と新規調節物質の創製･展開が期待されている。本研究においては, 自然免疫と獲得免疫の連携を担う外因性および内因性分子の化学合成法開発と機能解析, さらには新規制御分子創製を目指して研究を進めた。すなわち, 自然界に存在し免疫調節に関わると考えられる複合脂質および複合糖質について, 特に合成例の無い化合物を中心に合成法開発とライブラリ構築に成功した。また, 合成化合物を用い免疫調節作用を解析すると共に認識タンパク質との相互作用解析を行い, 構造活性相関を初めて示すとともに, 天然型および類縁構造を用い種々の免疫調節性化合物の役割解明を行った。
In this study, we first aimed to develop the chemical synthesis of exogenous and endogenous molecules responsible for cooperation between innate immunity and adaptive immunity, and also to analyze the function with using the synthesized compounds. We also aimed to design and produce new-types of molecules that can modulate the immune system. Namely, we first synthesized natural immunomodulatory compounds (especially glyco-conjugates and lipid-conjugates), and then analyzed the structure-activity relationships in the immunomodulatory activities and also the interaction with the recognition protein. Based on these results, the immunomodulatory functions of the natural and designed molecules were successfully shown.
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研究種目 : 基盤研究(B)(一般)
研究期間 : 2014～2016
課題番号 : 26282211
研究分野 : 生物有機化学
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