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KAKEN_25870719seika.pdf
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Download
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:155.3 KB
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:Jul 26, 2019 |
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Total downloads since Jul 26, 2019 : 726
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メタボロミクスを活用した膵臓がん特異的代謝機構の解明とマルチバイオマーカー探索
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メタボロミクス オ カツヨウシタ スイゾウガン トクイテキ タイシャ キコウ ノ カイメイ ト マルチ バイオマーカー タンサク
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Metaboromikusu o katsuyoshita suizogan tokuiteki taisha kiko no kaimei to maruchi baiomaka tansaku
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Elucidation of pancreatic cancer specific metabolism and biomarker discovery using metabolomics
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平山, 明由
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ヒラヤマ, アキヨシ
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Hirayama, Akiyoshi
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慶應義塾大学・政策・メディア研究科・特任助教
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Research team head
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科研費研究者番号 : 00572405
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2015
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科学研究費補助金研究成果報告書
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2014
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本研究では, キャピラリー電気泳動-質量分析法(CE-MS)を用いて, 膵臓がん組織, 膵液, 血清中のイオン性代謝物の一斉分析を行い, がん特異的な代謝, ならびにバイオマーカーの探索を行った。本研究によって, 5つのがん特異的な代謝経路, ならびに24個の血清バイオマーカー候補の抽出が可能であった。得られた知見は, 新たな膵臓がん代謝メカニズム解明の一助となる。
In this study, comprehensive analysis of charged metabolites extracted from pancreatic tumor tissue, pancreatic fluid and blood serum were performed by using capillary electrophoresis-mass spectrometry (CE-MS) in order to discover novel cancer-specific metabolism and biomarker candidates.
As a result, five pancreatic cancer-specific pathways and 24 serum biomarker candidates were highlighted in this study. This information will help to elucidate the metabolic mechanisms underlying pancreatic cancer.
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研究種目 : 若手研究(B)
研究期間 : 2013～2014
課題番号 : 25870719
研究分野 : メタボロミクス
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| Jul 26, 2019 | | 著者,抄録 内容,本文URI URI を変更 |
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