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KAKEN_25861214seika.pdf
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Title |
Title |
Atmと血管新生・EMTの関係および微小転移形成メカニズムについて
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Kana |
Atm ト ケッカン シンセイ・EMT ノ カンケイ オヨビ ビショウ テンイ ケイセイ メカニズム ニ ツイテ
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Romanization |
Atm to kekkan shinsei EMT no kankei oyobi bisho teni keisei mekanizumu ni tsuite
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Ataxia telangiectasia mutated relates to epithelial- : mesenchymal transition in colorectal cancer.
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山田, 暢
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Kana |
ヤマダ, トオル
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Romanization |
Yamada, Toru
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Affiliation |
慶應義塾大学・医学部・助教
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Research team head
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科研費研究者番号 : 50594727
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岡林, 剛史
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Kana |
オカバヤシ, コウジ
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Romanization |
Okabayashi, Koji
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Affiliation |
慶應義塾大学・医学部・助教
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Research team member
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科研費研究者番号 : 00338063
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鶴田, 雅士
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ツルタ, マサシ
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Romanization |
Tsuruta, Masashi
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Affiliation |
慶應義塾大学・医学部・助教
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Research team member
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科研費研究者番号 : 00348666
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高橋, 秀奈
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Kana |
タカハシ, ヒデナ
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Romanization |
Takahashi, Hidena
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Affiliation |
慶應義塾大学・医学部・助教
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Research team member
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科研費研究者番号 : 90594721
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久保田, 義顕
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クボタ, ヨシアキ
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Romanization |
Kubota, Yoshiaki
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慶應義塾大学・医学部・特任教授
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Research team member
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科研費研究者番号 : 50348687
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2015
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科学研究費補助金研究成果報告書
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2014
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Abstract |
近年大腸癌罹患率は増加しておりそれに伴い死亡率も上昇している。その多くは転移に伴う死亡であり, 転移に伴うメカニズムの解明が重要である。Atmは血管の安定性に関与する遺伝子であり, 近年腫瘍新生のバリアとして働くことが報告された。また, 癌細胞の浸潤・転移との関わりで注目されているEMT : 上皮間葉移行との関係も示唆されているが, 大腸癌におけるAtmとEMTの関係は示されていない。我々はAtm高発現大腸癌細胞株でEMTが亢進しAtmを抑制することでEMTが抑制されることを示し, 大腸癌におけるAtmとEMTの関係が示唆された。
Today, disease prevalence rate and the mortality rate of colorectal cancer is increasing. Since most of the cause of the death is related with the metastatic cancer , it is important to clarify the mechanism of metastasis of colorectal cancer. Atm is known as on of the genes which is related to stability of the blood vessels. Recently, the relationship between Atm and EMT(Epithelial-Mesenchymal Transition) which is known as one of the important mechanism of the invasion and metastasis of cancer cells is become clear. However their relationship is not proven in colorectal cancer cells/tissue.
In our experiment, it is revealed that EMT is enhanced in Atm-hyperexpression colon cancer cells. And in these cells, EMT is inhibited through the inhibition of Atm. Thus, the relationship of Atm and EMT in colorectal cancer was suggested.
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研究種目 : 若手研究(B)
研究期間 : 2013~2014
課題番号 : 25861214
研究分野 : 外科
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Jul 29, 2019 | | 著者 を変更 |
Aug 2, 2019 | | 著者 を変更 |
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