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KAKEN_25860396seika.pdf
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:154.5 KB
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:Apr 11, 2016 |
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エズリンをシードジーンとする胎盤機能制御遺伝子ネットワーク解析
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エズリン オ シードジーン ト スル タイバン キノウ セイギョ イデンシ ネットワーク カイセキ
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Ezurin o shidojin to suru taiban kino seigyo idenshi nettowaku kaiseki
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Gene network analysis of placental function regulators and a seed gene, ezrin
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西村, 友宏
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ニシムラ, トモヒロ
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Nishimura, Tomohiro
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慶應義塾大学・薬学部・専任講師
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Research team head
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科研費研究者番号 : 40453518
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2015
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科学研究費補助金研究成果報告書
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2014
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妊娠時における胎児発育不全を回避するためには胎盤機能の解明が重要である。エズリンは胎盤に発現する細胞膜タンパク質の調節因子であり, エズリンの機能不全は胎児発育不全に繋がる。本研究はエズリンの機能不全が胎児発育不全を惹起する機構を解明するため, エズリンが作用する標的遺伝子と胎児発育不全関連遺伝子群との関連を情報学的および実験的に情報収集し, 胎児発育不全関連遺伝子ネットワークを構築することを目的とした。エズリンは既知の胎児発育不全関連遺伝子との直接的な関係性は得られず, 新規の機構により胎児発育不全を呈する可能性がある。
Placental function plays important roles in the fetal growth. Ezrin is a regulatory gene for plasma membrane proteins in the placenta, and deficiency of ezrin induces fetal growth retardation (FGR). This study aimed to clarify a gene network between ezrin and the other genes responsible for FGR by means of informatics and experiments in order to understand the molecular mechanism of the ezrin-mediated FGR. Network analysis showed no direct relationship between ezrin and the known FGR-related genes, indicating that ezrin-mediated FGR includes the novel molecular mechanism. We further analyzed protein interaction between Ezrin and a hypotaurine transporter, SLC6A13 in the placenta, since Ezrin knockout fetal mice showed deficiency of hypotaurine. Ezrin and SLC6A13 are co-localized on the plasma membrane in the labyrinth zone of mouse placenta. These results indicate that a novel interaction between Ezrin and SLC6A13 is important for fetal growth.
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研究種目 : 若手研究(B)
研究期間 : 2013～2014
課題番号 : 25860396
研究分野 : 生物薬剤学
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