Item Type |
Article |
ID |
|
Preview |
Image |
|
Caption |
|
|
Full text |
KAKEN_25670737seika.pdf
Type |
:application/pdf |
Download
|
Size |
:358.8 KB
|
Last updated |
:Jul 29, 2019 |
Downloads |
: 495 |
Total downloads since Jul 29, 2019 : 495
|
|
Release Date |
|
Title |
Title |
涙液分泌とエネルギー代謝
|
Kana |
ルイエキ ブンピツ ト エネルギー タイシャ
|
Romanization |
Ruieki bunpitsu to enerugi taisha
|
|
Other Title |
Title |
The energy metabolism and tear secretion
|
Kana |
|
Romanization |
|
|
Creator |
Name |
坪田, 一男
|
Kana |
ツボタ, カズオ
|
Romanization |
Tsubota, Kazuo
|
Affiliation |
慶應義塾大学・医学部・教授
|
Affiliation (Translated) |
|
Role |
Research team head
|
Link |
科研費研究者番号 : 40163878
|
Name |
鳥居, 秀成
|
Kana |
トリイ, ヒデマサ
|
Romanization |
Torii, Hidemasa
|
Affiliation |
慶應義塾大学・医学部・助教
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
科研費研究者番号 : 50445326
|
|
Edition |
|
Place |
|
Publisher |
|
Date |
Issued (from:yyyy) |
2015
|
Issued (to:yyyy) |
|
Created (yyyy-mm-dd) |
|
Updated (yyyy-mm-dd) |
|
Captured (yyyy-mm-dd) |
|
|
Physical description |
|
Source Title |
Name |
科学研究費補助金研究成果報告書
|
Name (Translated) |
|
Volume |
|
Issue |
|
Year |
2014
|
Month |
|
Start page |
|
End page |
|
|
ISSN |
|
ISBN |
|
DOI |
|
URI |
|
JaLCDOI |
|
NII Article ID |
|
Ichushi ID |
|
Other ID |
|
Doctoral dissertation |
Dissertation Number |
|
Date of granted |
|
Degree name |
|
Degree grantor |
|
|
Abstract |
糖尿病モデルであるdb/dbマウスを用いてメタボリックシンドロームがおよぼす涙液機能への変化を検討した。糖尿病モデルとしてdb/dbマウスを使用し体重および涙液量を測定した。涙液機能の検査はマウスを無麻酔で補綴後, 綿糸を眼瞼下部に挿入し30秒間の涙液測定を行った。左右の涙液貯留量を測定し, 涙液量とした。経時的に体重および涙液を測定した結果, db/dbマウスの体重はdb/mマウスと比べて高値を示した。db/dbマウスの涙液分泌量はdb/mマウスと比べて有意に低値を示した。血液生化学的検査の結果血糖値が有意に高値を示した。以上から涙液機能低下にはエネルギー代謝が変化していることが明らかとなった。
The db/db mice were the animal model for a rodent model of type 2 diabetes. We investigated the molecular mechanism of tear secretion and metabolic changes.
We used db/db mice and their non-diabetic db/m mice in all experiments. Measurement of tear secretion was performed once a month with a phenol red thread. It was placed on the temporal side of the lower eyelid margin for 30 seconds. After measurement, the mice were sacrificed, lacrimal gland extirpated and lacrimal gland were used all experiments. Serum samples were collected for biochemical analysis. Body weight of db/db mice were significantly increased than db/m mice. In the biochemical analysis of the serum, blood glucoce were significantly higher in the db/db group than in the db/m. At the 3-month time-point of the experiment, tear secretion was decreased by the db/db mice compared to the db/m mice. We concluded those energy metabolism genes are key molecules for tear secretion.
|
|
Table of contents |
|
Keyword |
|
NDC |
|
Note |
研究種目 : 挑戦的萌芽研究
研究期間 : 2013~2014
課題番号 : 25670737
研究分野 : ドライアイ
|
|
Language |
|
Type of resource |
|
Genre |
|
Text version |
|
Related DOI |
|
Access conditions |
|
Last modified date |
|
Creation date |
|
Registerd by |
|
History |
Jul 29, 2019 | | 著者,著者版フラグ を変更 |
|
|
Index |
|
Related to |
|