Item Type |
Article |
ID |
|
Preview |
Image |
|
Caption |
|
|
Full text |
KAKEN_25462612seika.pdf
Type |
:application/pdf |
Download
|
Size |
:101.9 KB
|
Last updated |
:Aug 28, 2023 |
Downloads |
: 770 |
Total downloads since Aug 28, 2023 : 770
|
|
Release Date |
|
Title |
Title |
MMR異常が高頻度の子宮体癌における腫瘍免疫変化と抗癌剤ホルモン剤感受性との関連
|
Kana |
MMR イジョウ ガ コウヒンド ノ シキュウタイガン ニ オケル シュヨウ メンエキ ヘンカ ト コウガンザイ ホルモンザイ カンジュセイ トノ カンレン
|
Romanization |
MMR ijo ga kohindo no shikyutaigan ni okeru shuyo meneki henka to koganzai horumonzai kanjusei tono kanren
|
|
Other Title |
Title |
Alteration of tumor immunity and anti-cancer drug/hormone sensitivity in endometrial cancer with frequent MMR mechanism abnormality
|
Kana |
|
Romanization |
|
|
Creator |
Name |
進, 伸幸
|
Kana |
ススム, ノブユキ
|
Romanization |
Susumu, Nobuyuki
|
Affiliation |
慶應義塾大学・医学部・准教授
|
Affiliation (Translated) |
|
Role |
Research team head
|
Link |
科研費研究者番号 : 90206459
|
Name |
山上, 亘
|
Kana |
ヤマガミ, ワタル
|
Romanization |
Yamagami, Wataru
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
野田, 朋美
|
Kana |
ノダ, トモミ
|
Romanization |
Noda, Tomomi
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
坂井, 健良
|
Kana |
サカイ, ケンスケ
|
Romanization |
Sakai, Kensuke
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
真壁, 健
|
Kana |
マカベ, タケシ
|
Romanization |
Makabe, Takeshi
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
二宮, 委美
|
Kana |
ニノミヤ, トモミ
|
Romanization |
Ninomiya, Tomomi
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
平沢, 晃
|
Kana |
ヒラサワ, アキラ
|
Romanization |
Hirasawa, Akira
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
片岡, 史夫
|
Kana |
カタオカ, フミオ
|
Romanization |
Kataoka, Fumio
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
野村, 弘行
|
Kana |
ノムラ, ヒロユキ
|
Romanization |
Nomura, Hiroyuki
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
阪埜, 浩司
|
Kana |
バンノ, コウジ
|
Romanization |
Banno, Koji
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
Name |
青木, 大輔
|
Kana |
アオキ, ダイスケ
|
Romanization |
Aoki, Daisuke
|
Affiliation |
|
Affiliation (Translated) |
|
Role |
Research team member
|
Link |
|
|
Edition |
|
Place |
|
Publisher |
|
Date |
Issued (from:yyyy) |
2016
|
Issued (to:yyyy) |
|
Created (yyyy-mm-dd) |
|
Updated (yyyy-mm-dd) |
|
Captured (yyyy-mm-dd) |
|
|
Physical description |
|
Source Title |
Name |
科学研究費補助金研究成果報告書
|
Name (Translated) |
|
Volume |
|
Issue |
|
Year |
2015
|
Month |
|
Start page |
|
End page |
|
|
ISSN |
|
ISBN |
|
DOI |
|
URI |
|
JaLCDOI |
|
NII Article ID |
|
Ichushi ID |
|
Other ID |
|
Doctoral dissertation |
Dissertation Number |
|
Date of granted |
|
Degree name |
|
Degree grantor |
|
|
Abstract |
MSI陽性の子宮体癌では, 腫瘍浸潤CD8陽性リンパ球(TIL)数が高値で, COX-2高発現例ではTIL数は低値で, 多変量解析で, TIL低値, リンパ節転移陽性, 低分化が独立した予後不良因子であった。MSI陽性例にてもCOX-2高発現例は予後不良で, COX-2発現はMSI-高TIL数による腫瘍免疫を抑制する可能性が示唆された。また, 内膜異型増殖症や高分化型子宮体癌の214例に妊孕性温存黄体ホルモン療法を施行し, 再発後に反復治療を施行した症例でも安全に治療を遂行でき, 初回治療後と反復治療後で併せて62例で83回の妊娠を得た。重複癌の発生頻度は7.5%で, 反復治療にて重複癌の発生頻度は上昇しなかった。
The MSI-positive tumors showed significantly higher grades and larger numbers of TILs than MSI-negative tumors. The COX-2-high group showed fewer TILs than COX-2-low group. Multivariate analysis identified a low number of TILs, positive lymph node involvement, and high tumor malignancy grade as factors independently associated with poor prognosis. The number of TILs, which was increased by MSI and decreased by COX-2 expression, was associated with a poorer prognosis in patients with endometrial cancer. We also propose that COX-2 may block MSI-activated TILs in the tumor microenvironment. Regarding fertility-preserving hormonal therapy, we performed hormonal therapy for 214 young patients with atypical endometrial hyperplasia or endometrioid adenocarcinoma G1. We succeeded in 83 pregnancies in 62 patients and showed 7.5% as the frequency of double cancer, and also revealed the safety and effectiveness of repeated MPA therapy after recurrence with the low incidence of double cancer.
|
|
Table of contents |
|
Keyword |
|
NDC |
|
Note |
研究種目 : 基盤研究(C)(一般)
研究期間 : 2013~2015
課題番号 : 25462612
研究分野 : 医歯薬学
|
|
Language |
|
Type of resource |
|
Genre |
|
Text version |
|
Related DOI |
|
Access conditions |
|
Last modified date |
|
Creation date |
|
Registerd by |
|
History |
Aug 28, 2023 | | Creator,Abstract 内容,Note 注記 を変更 |
|
|
Index |
|
Related to |
|