thermal sink effectの定量化を目的として, 流体循環ポンプシステムを用いて模擬血管・血流の条件(血管径, 血流量, 近接距離)を変化させながら, ゲル中の凍結端子周囲に作成されるアイスボールのサイズ, 形状の変化をCT下に観察した。その結果, 模擬thermal sink effectは模擬血管径, 血流量に相関して拡大し, 模擬血管・凍結端子間の距離に逆相関することが確認された。同時に, アイスボール断面積の拡大抑制(thermal sink effect)が変化しなくなる血流量の上限があることも示された。さらに豚肝実験でもthermal sink effectを観察する手法が確立できた。
In order to quantify the thermal sink effect, the shape, the size and the volume of ice balls in gel created around a cryoprobe were successfully visualized and measured under computed tomography, while varying the factors (the diameter, the flow rate and the distance from the cryoprobe) of a simulated vascular flow generated by a custom-made fluid-circulating pump system. According to our results, the simulated thermal sink effect had a good correlation with the diameter and the flow rate of the simulated vessel, while there was an opposite correlation between the thermal sink effect and the distance from the cryoprobe. In addition, it was revealed that there was an upper limit of the thermal sink effect with regard to the flow rate of the simulated vessel. In a swine liver, the thermal sink effect was successfully visualized by this fluid-circulating pump system to utilize for a future experiment.

研究種目 : 基盤研究(C)(一般)
研究期間 : 2013～2015
課題番号 : 25461890
研究分野 : 医歯薬学