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KAKEN_25461608seika.pdf
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Download
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:92.9 KB
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:Jan 6, 2017 |
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Total downloads since Jan 6, 2017 : 686
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ゲノム情報および遺伝子発現に基づく小児Ph染色体陽性白血病の創薬標的候補探索研究
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ゲノム ジョウホウ オヨビ イデンシ ハツゲン ニ モトズク ショウニ Ph センショクタイ ヨウセイ ハッケツビョウ ノ ソウヤク ヒョウテキ コウホ タンサク ケンキュウ
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Genomu joho oyobi idenshi hatsugen ni motozuku shoni Ph senshokutai yosei hakketsubyo no soyaku hyoteki koho tansaku kenkyu
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Genome- and gene expression-based drug discovery for pediatric Philadelphia chromosome positive leukemia
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嶋田, 博之
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シマダ, ヒロユキ
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Shimada, Hiroyuki
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慶應義塾大学・医学部・講師
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Research team head
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科研費研究者番号 : 80265868
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嶋, 晴子
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シマ, ハルコ
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Shima, Haruko
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慶應義塾大学・医学部・助教
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Research team member
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科研費研究者番号 : 80424167
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清河, 信敬
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キヨカワ, ノブタカ
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Kiyokawa, Nobutaka
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独立行政法人国立成育医療研究センター・小児血液・腫瘍研究部・部長
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Research team member
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科研費研究者番号 : 60195401
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2016
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科学研究費補助金研究成果報告書
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2015
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| Abstract |
難治性白血病であるフィラデルフィア染色体陽性急性リンパ性白血病(Ph+ALL)の約80%にIKZF1遺伝子の欠失を認めたとの報告があり, 小児Ph+ALL患者を対象に, IKZF1欠失の有無と予後との関係を調べた。再発のない4年生存率は, IKZF1欠失のない患者が89%であったのに対し, IKZF1欠失のある患者は42%だった。IKZF1欠失のある患者の方が有意に再発率が高く, Ph+ALLが難治性であるのは, Ph染色体の形成より, IKZF1欠失に強く関係することが分かった。
Deletion of IKZF1 gene was reported to be found in 80% of pediatric Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL), which is known to be refractory leukemia. We examined the association between IKZF1 deletion and prognosis of 40 Ph+ALL patients, who was registered into the JPLSG Ph+ALL04 study. As a result, 4-year event-free survival was 89% in patients without IKZF1 deletion and 42% in patients with IKZF1 deletion. Patients with IKZF1 deletion had a significantly higher rate of relapse than those without IKZF1 deletion. These results suggest that the reason why Ph+ALL is refractory is not the appearance of Ph-chromosome but deletion of IKZF1.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2013～2015
課題番号 : 25461608
研究分野 : 小児血液・腫瘍
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