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KAKEN_25330348seika.pdf
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Download
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:166.3 KB
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:Sep 21, 2017 |
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Total downloads since Sep 21, 2017 : 292
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| Title |
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高次構造を考慮した超高速RNA構造アラインメント
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| Kana |
コウジ コウゾウ オ コウリョシタ チョウコウソク RNA コウゾウ アラインメント
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Koji kozo o koryoshita chokosoku RNA kozo arainmento
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Ultra-fast RNA structural alignments with pseudoknots
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佐藤, 健吾
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サトウ, ケンゴ
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Sato, Kengo
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慶應義塾大学・理工学部・講師
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Research team head
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科研費研究者番号 : 20365472
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2017
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科学研究費補助金研究成果報告書
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2016
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RNA構造アラインメントは古くから研究されているにも関わらず, 未だに計算量が大きいという問題がある。このため, 長鎖非コードRNAやRNAウィルスのような比較的長いRNA配列に関しては, 「配列を比べる」という基本的な解析すら厳密手法では満足に行えない状況である。本研究では, 期待精度最大化と双対分解に基づく革新的なアルゴリズムにより, シュードノットなどの複雑な高次構造を考慮したRNA構造アラインメントを高速かつ高精度に計算する手法を開発した。
Despite the fact that RNA structural alignments have been studied for a long time, there is still a problem that the computational complexity is still large. For this reason, we cannot perform even a basic analysis of "comparing sequences" by exact methods for relatively long RNA sequences such as long non-coding RNAs and RNA viruses. In this research, we developed a fast and accurate method of calculating RNA structural alignments with consideration of complicated higher order structures such as pseudoknots by a novel algorithm based on maximizing the expected accuracy and the dual decomposition.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2013～2016
課題番号 : 25330348
研究分野 : バイオインフォマティクス
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