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KAKEN_25293356seika.pdf
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Title |
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抗加齢学的アプローチによる涙液分泌制御機構の解明
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コウカレイガクテキ アプローチ ニ ヨル ルイエキ ブンピ セイギョ キコウ ノ カイメイ
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Kokareigakuteki apurochi ni yoru ruieki bunpi seigyo kiko no kaimei
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Elucidation of the mechanism to control tear secretion by anti-aging approach
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坪田, 一男
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ツボタ, カズオ
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Tsubota, Kazuo
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慶應義塾大学・医学部・教授
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Research team head
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科研費研究者番号 : 40163878
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2016
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科学研究費補助金研究成果報告書
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2015
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加齢および生活習慣病によって誘発されるドライアイの病態解明へ貢献することを目的に生活習慣病を発症するマウスを用いて涙腺組織における加齢関連分子の解明および加齢進行の抑制が期待できる抗酸化作用を有する機能性食品因子の効果を検討した。その結果, 加齢関連分子が生活習慣病発症マウスにおいて有意に低値を示した。また, 機能性食品因子を投与することによって, 涙液分泌量の増加が認められたこと, 分泌関連分子が増加していたことが明らかとなった。以上の結果は, 加齢とドライアイに生活習慣病が密接な関係であることを明らかにし, ドライアイ病態の解明および治療法を開発する上で非常に意義深いと考えられる。
A purpose of this study is to contribute to condition of a patient elucidation of dry eye syndrome caused by aging and a lifestyle-related disease. By using life style-related disease developing mice, we examined the elucidation of age related molecules and effect of the functional foods factor which had the antioxidant action in the lacrimal glands. As a result, aging-related molecules significantly showed a low value in a lifestyle-related disease developing mice. In addition, it became clear that increase in tear secretion volume and secretion-related molecules by giving a functional foods factor. We demonstrated that the aging and dry eye syndrome are a close relationship to a lifestyle-related disease. Our findings should be crucial in condition of a patient elucidation and therapeutic treatment of dry eye syndrome.
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研究種目 : 基盤研究(B)(一般)
研究期間 : 2013~2015
課題番号 : 25293356
研究分野 : ドライアイ
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