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KAKEN_25282135seika.pdf
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Download
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:90.7 KB
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:Jan 6, 2017 |
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Total downloads since Jan 6, 2017 : 248
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| Title |
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間質流制御に基づく血管化組織工学の展開
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| Kana |
カンシツリュウ セイギョ ニ モトズク ケッカンカ ソシキ コウガク ノ テンカイ
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Kanshitsuryu seigyo ni motozuku kekkanka soshiki kogaku no tenkai
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Development of tissue engineering for vascularization based on regulation of interstitial flow
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須藤, 亮
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スドウ, リョウ
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Sudo, Ryo
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慶應義塾大学・理工学部・准教授
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Research team head
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科研費研究者番号 : 20407141
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谷下, 一夫
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タニシタ, カズオ
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Tanishita, Kazuo
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早稲田大学・ナノ・ライフ創新研究機構・上級研究員(研究院教授)
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Research team member
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科研費研究者番号 : 10101776
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三高, 俊広
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ミタカ, トシヒロ
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Mitaka, Toshihiro
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札幌医科大学・医学部・教授
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Research team member
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科研費研究者番号 : 50231618
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牛山, 明
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ウシヤマ, アキラ
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Ushiyama, Akira
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国立保健医療科学院・生活環境研究部・上席主任研究官
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Research team member
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科研費研究者番号 : 60291118
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2016
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科学研究費補助金研究成果報告書
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2015
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| Abstract |
現在の組織工学では複雑な三次元臓器の再生手法が必要とされている。特に, 毛細血管を含む三次元複合組織の再生が課題であり, 本研究は生体工学の立場から三次元肝細胞組織に毛細血管を導入する血管化の技術を検討した。具体的には, 3チャンネル型マイクロ流体デバイスにおいて血管形成と三次元肝組織形成の時期を調節することで, 三次元肝組織に血管組織を導入することに成功し, 再現性を確認した。さらに, 肝細胞調整培養液やコラーゲンゲル粒子を用いることによって効率を高める可能性を示した。
It is necessary to reconstruct three-dimensional (3D) complex organs in current tissue engineering. In particular, construction 3D complex tissues including microvascular networks is a big challenge. In this study, we investigated a technology to vascularize 3D hepatocyte tissues. Specifically, we could construct 3D hepatocyte tissues with microvessels by controlling the timing of vascular formation and hepatocyte tissue formation in 3-channel microfluidic devices. Furthermore, we demonstrated hepatocyte-conditioned medium and collagen gel microspheres could promote vascularization of hepatocyte tissues.
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研究種目 : 基盤研究(B)(一般)
研究期間 : 2013～2015
課題番号 : 25282135
研究分野 : 組織工学, 生体工学
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