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KAKEN_24791671seika.pdf
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上部尿路上皮癌におけるレニンアンギオテンシン系の制御を利用した新規治療の確立
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ジョウブ ニョウロ ジョウヒガン ニ オケル レニン アンギオテンシンケイ ノ セイギョ オ リヨウ シタ シンキ チリョウ ノ カクリツ
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Jobu nyoro johigan ni okeru renin angiotenshinkei no seigyo o riyo shita shinki chiryo no kakuritsu
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The efficacy of renin-angiotensin system blockade for upper tract urothelial carcinoma
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田中, 伸之
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タナカ, ノブユキ
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Tanaka, Nobuyuki
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慶應義塾大学・医学部・講師(非常勤)
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Research team head
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科研費研究者番号 : 60445244
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2014
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科学研究費補助金研究成果報告書
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2013
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国内間多施設共同データベースを用いた後ろ向き解析により、上部尿路上皮癌患者ではレニンアンギオテンシン系(RAS)阻害剤内服の有無が術後再発に関連する独立した危険因子であり、術後補助治療としてのRAS制御の有効性が確認された。更に上部尿路上皮癌手術検体を用いた免疫組織学的評価でも血管新生のパラメーターである微小血管密度が有意に予後と関連し、その調節因子であるRAS制御の重要性が示唆された。
Using a multi-institutional and retrospective cohort of patients with upper tract urothelial carcinoma (UTUC) in Japan, we found that the absence of renin-angiotensin system (RAS) inhibitors was significantly associated with disease recurrence following radical nephroureterectomy independent of other clinicopathological parameter, suggesting RAS inhibition might be effective to prevent subsequent relapsing in UTUC. Moreover, immunohistochemical analysis in surgical specimens revealed that the microvessel density in tumors was significantly associated with oncological outcome in UTUC patients, suggesting the importance of its upper modulator of RAS regulation in UTUC.
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研究種目 : 若手研究(B)
研究期間 : 2012～2013
課題番号 : 24791671
研究分野 : 医歯薬学
科研費の分科・細目 : 外科系臨床医学・泌尿器科学
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