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KAKEN_24500448seika.pdf
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| Title |
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ガス分子依存性多元的情報伝達系を標的とした脳エネルギー代謝・血流制御機構の解明
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ガス ブンシ イゾンセイ タゲンテキ ジョウホウ デンタツケイ オ ヒョウテキ ト シタ ノウ エネルギー タイシャ・ケツリュウ セイギョ キコウ ノ カイメイ
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Gasu bunshi izonsei tagenteki joho dentatsukei o hyoteki to shita no enerugi taisha ketsuryu seigyo kiko no kaimei
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Gas-dependent mechanisms for neurovascular coupling
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梶村, 眞弓
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カジムラ, マユミ
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Kajimura, Mayumi
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慶應義塾大学・医学部・准教授
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Research team head
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科研費研究者番号 : 10327497
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石川, 眞実
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イシカワ, マミ
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Ishikawa, Mami
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自治医科大学・医学部・准教授
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Research team member
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科研費研究者番号 : 60212859
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2015
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科学研究費補助金研究成果報告書
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2014
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ガスを含む低分子代謝物は, 金属と相互作用して微弱な振動分光学的信号を発する性質をもつ。また金属ナノ粒子の表面に吸着した分子のラマン散乱強度が, 数桁も増強する現象が発見され, シグナル増強に活用されるようになった。我々は, アルミの水熱処理によってベーマイトというナノ微細凹凸構造が容易に形成されることを利用し, その上に金原子を蒸着し, 高い表面増強ラマン散乱活性を有する"Gold Nanocoral"(金のナノサンゴ礁)という新規ナノ構造の量産開発に成功したラマンイメージング技術を駆使すると, 広い視野で生体ガス分子の分布や量が超高感度でアセスメントできる可能性がある。
Application of SERS for tissue-imaging has been limited because of technical constraints to fabricate a SERS substrate ensuring hot-spot formation uniformly over a large area with ease. To overcome this hurdle, we used the boehmite nanostructure easily achieved by immersing the aluminum film in boiling water. Sharp geometry of boehmite is an efficient template for the gold deposition ensuring strong enhancement of SERS signals. This simple method made it possible to produce a SERS substrate with a size of a square centimeter order, the dimension necessary to accommodate most tissue samples. GNC substrate enabled the large-area SERS imaging to visualize an ischemic core of mouse brain tissue without labeling for the first time. SERS has strength in visualizing metabolites as they exist in the tissue without any chemical pretreatment. We believe that this devise will give rise to new insights to characterize gas-dependent metabolic interactions between distinct regions of tissues.
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研究種目 : 基盤研究(C)
研究期間 : 2012～2014
課題番号 : 24500448
研究分野 : 神経科学, 神経化学, 神経薬理学
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