マウス背部の組織の肉眼的所見としては, 創作成後14日目に隆起・発赤が強くなっていた。この変化は28日まで確認できたが, その後は徐々に軽快していく状態であった。同部の瘢痕を回収して免疫染色を行ったところ, 通常の瘢痕と比較して, 張力を負荷した肥厚性瘢痕モデル群においては優位にT細胞の発現を認めた。これはヒトに近いブタ瘢痕モデルにおいても同様の結果を得た。そこでＴ細胞の発現を抑制するスプラタストトシル酸塩の経口投与を行ってマウス背部に張力をかけて瘢痕の形成を試みたが, 肥厚性瘢痕の形成は認めれらなった。
As macroscopic views of the scar of the mouse, the wound of 14 days after wound making was like hypertrophy. This chage could be confirmed until 28 days. After 28days, the wound was going to be gradually relieved. The scar was harvested, and immunostained, it was recognized the expression of the T cell in predominance in the hyperplastic scar model group that burdened the tension in comparison with a normal scar. This result was obtained the pig scar model whoich skin contructure was near to Homo sapiens. Therefore, gave the Suplatast tosilate which controlled the expression of T cell, and tried the formation of the scar, but the formation of the hyperplastic scar was not recognized.
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