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KAKEN_23390178seika.pdf
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Download
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:172.1 KB
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:Apr 8, 2016 |
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Total downloads since Apr 8, 2016 : 653
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| Title |
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酸化LDLコレステロールと潜在性動脈硬化症、生活機能の関連についての地域疫学研究
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| Kana |
サンカ LDL コレステロール ト センザイセイ ドウミャク コウカショウ, セイカツ キノウ ノ カンレン ニ ツイテ ノ チイキ エキガク ケンキュウ
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Sanka LDL koresuteroru to senzaisei domyaku kokasho, seikatsu kino no kanren ni tsuite no chiiki ekigaku kenkyu
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The effect of soluble form LOX-1 and LOX-1 ligands containing apolipoprotein B on subclinical atherosclerosis in community dwellers..
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岡村, 智教
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オカムラ, トモノリ
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Okamura, Tomonori
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慶應義塾大学・医学部・教授
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Research team head
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科研費研究者番号 : 00324567
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宮本, 恵宏
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ミヤモト, ヨシヒロ
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Miyamoto, Yoshihiro
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国立循環器病研究センター・予防健診部・部長
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Research team member
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科研費研究者番号 : 10312224
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西脇, 祐司
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ニシワキ, ユウジ
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Nishiwaki, Yuji
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東邦大学・医学部・教授
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Research team member
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科研費研究者番号 : 40237764
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東山, 綾
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ヒガシヤマ, アヤ
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Higashiyama, Aya
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兵庫医科大学・医学部・助教
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Research team member
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科研費研究者番号 : 20533003
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沢村, 達也
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サワムラ, タツヤ
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Sawamura, Tatsuya
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国立循環器病研究センター・血管生理部・部長
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Research team member
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科研費研究者番号 : 30243033
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三浦, 克之
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ミウラ, カツユキ
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Miura, Katsuyuki
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滋賀医科大学・医学部・教授
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Research team member
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科研費研究者番号 : 90257452
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上島, 弘嗣
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ウエシマ, ヒロツグ
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Ueshima, Hirotsugu
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滋賀医科大学・アジア疫学研究センター・特任教授
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Research team member
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科研費研究者番号 : 70144483
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Sekikawa, Akira
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セキカワ, アキラ
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Associate Professor University of Pittsburgh
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Research team member
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2015
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科学研究費補助金研究成果報告書
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2014
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| Abstract |
LOX-1は, 内皮細胞における変性LDLの受容体である。そこでApoB含有LOX-1リガンド(LAB)と潜在的な動脈硬化所見の関連をみた。40歳代男性では, 米国集団ではLDLCを調整してもLABと頸動脈IMTに有意な正の関連を認めた。しかし日本人集団では関連を認めなかった。平均年齢67歳の日本人集団ではLABと頸動脈IMTに有意な関連を認めたが, LDLCを調整すると有意差は消失した。神戸市の男女 515人では, LDLCを調整してもLABはCAVIと有意な正の関連を示した。通常, IMTよりCAVIのほうがより早期の動脈硬化の指標であるため, LABは日本人の動脈硬化の早期指標として意義がある。
The serum level of LOX-1 ligand containing ApoB (LAB) may reflect atherogenicity better than LDL cholesterol (LDLC) and usual measurement of oxidized LDL. The association between LAB and subclinical atherosclerosis, such as intima-media thickness (IMT) of carotid artery and Cardio Ankle Vascular Index, CAVI, was investigated in community dwellers. In group with a mean age of 45, serum LAB was associated with an increased carotid IMT in US Caucasian men independently of various risk factors (N= 297) ; however, there was no significant relationship between LAB and IMT in Japanese men (N= 310). In other Japanese group with a mean age of 64 (N= 992), serum LAB was associated with an increased carotid IMT only in men with hypercholesterolemia. In 515 healthy Japanese (310 men and 205 women) living in Kobe city, the plasma LAB showed a positive association with the CAVI in men but not in women. LAB may be a useful marker for detecting early stage of atherosclerosis in "healthy" individuals.
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研究種目 : 基盤研究(B)
研究期間 : 2011～2014
課題番号 : 23390178
研究分野 : 公衆衛生学
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