| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_23240053seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:543.5 KB
|
| Last updated |
:Jan 6, 2017 |
| Downloads |
: 660 |
Total downloads since Jan 6, 2017 : 660
|
|
| Release Date |
|
| Title |
| Title |
シナプス可塑性を支える新しいAMPA受容体輸送制御機構の解明
|
| Kana |
シナプス カソセイ オ ササエル アタラシイ AMPA ジュヨウタイ ユソウ セイギョ キコウ ノ カイメイ
|
| Romanization |
Shinapusu kasosei o sasaeru atarashii AMPA juyotai yuso seigyo kiko no kaimei
|
|
| Other Title |
| Title |
Molecular mechanisms underlying AMPA receptor trafficking during synaptic plasticity
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
柚崎, 通介
 |
| Kana |
ユザキ, ミチスケ
|
| Romanization |
Yuzaki, Michisuke
|
| Affiliation |
慶應義塾大学・医学部・教授
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 40365226
|
| Name |
幸田, 和久
|
| Kana |
コウダ, カズヒサ
|
| Romanization |
Koda, Kazuhisa
|
| Affiliation |
慶應義塾大学・医学部・准教授
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
科研費研究者番号 : 40334388
|
| Name |
掛川, 渉
|
| Kana |
カケガワ, ワタル
|
| Romanization |
Kakegawa, Wataru
|
| Affiliation |
慶應義塾大学・医学部・専任講師
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
科研費研究者番号 : 70383718
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2016
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2015
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
シナプス伝達の長期抑圧(LTD)現象は記憶・学習の基礎過程であり, シナプス後膜におけるAMPA受容体の減少によって起きる。LTDは, 1) AMPA受容体を足場分子から外す, 2) AMPA受容体をエンドサイトーシスする, の2つの過程からなる。これまで後者の過程を担う機構はよく分かっていなかった。また小脳LTDになぜデルタ2型グルタミン酸受容体(GluD2)が必要なのかも謎であった。今回の研究により, GluD2はAMPA受容体の足場タンパク質からの外れやすさを調節することが判明した。また神経活動に応じてエンドサイトーシスに必要な分子AP-2が集積しAMPA受容体と結合することが分かった。
It is believed that long-term depression (LTD) is mediated by AMPA receptor endocytosis at the postsynaptic site. During LTD, AMPA receptors are first liberated from their anchoring proteins at the postsynaptic site, diffuse to the perisynaptic site, where endocytosis takes place. However how AMPA receptors are selectively endocytosed remained largely unclear. In addition, it has been a mystery why the delta2 glutamate receptor (GluD2) is crucial for induction of cerebellar LTD. In this study, we found that GluD2 determined whether anchoring proteins were dissociated from AMPA receptors. In addition, we found how clathrin adaptor protein AP-2, an essential molecule for clathrin-dependent endocytosis, accumulated at the perisynaptic site and recognized the AMPA receptor complex during LTD.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 基盤研究(A)(一般)
研究期間 : 2011～2015
課題番号 : 23240053
研究分野 : 神経生物学
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
|
| Index |
|
| Related to |
|
