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KAKEN_18K19937seika.pdf
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:88.8 KB
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血管新生と神経新生の融合による三次元脳組織工学の開拓
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ケッカン シンセイ ト シンケイ シンセイ ノ ユウゴウ ニ ヨル サンジゲン ノウ ソシキ コウガク ノ カイタク
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Kekkan shinsei to shinkei shinsei no yūgō ni yoru sanjigen nō soshiki kōgaku no kaitaku
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Development of three-dimensional brain tissue engineering by the combination of angiogenesis and neurogenesis models
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須藤, 亮
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スドウ, リョウ
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Sudō, Ryō
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慶應義塾大学・理工学部 (矢上) ・准教授
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Research team head
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科研費研究者番号 : 20407141
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2020
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科学研究費補助金研究成果報告書
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2019
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本研究では組織工学の観点から、マイクロ流体デバイスを用いた三次元培養によって脳の三次元ユニット構造であるNeurovascular Unit (NVU) を再現することを目的とした。まず血管新生モデルの開発に注力し、次に神経新生モデルと組み合わせる方針で研究を進めた。まず初めに血管および神経それぞれの培養モデルの共通の培養プラットフォームとなるマイクロ流体デバイスを作製し、脳組織工学に適した血管新生モデルを検討した。次に、脳の発生段階を模擬することによって脳血管新生モデルを構築した。これらの結果に基づいて、最終的に血管新生と神経新生の融合に取り組み、三次元NVU培養モデルの構築に成功した。
The purpose of this study is to construct a culture model of neurovascular unit, which is a three-dimensional (3D) unit structure in the brain, by 3D culture in a microfluidic device from the standpoint of tissue engineering. This study was conducted by focusing on the development of an angiogenesis model, which was followed by the combination of the angiogenesis model and a neurogenesis model. First, we constructed a microfluidic device, which is a common culture platform for both angiogenesis and neurogenesis models. We then investigated an angiogenesis model which is useful in brain tissue engineering. Furthermore, we constructed a brain angiogenesis model by recapitulating brain developmental stages. Finally, we successfully constructed a 3D NVU culture model by combining angiogenesis and neurogenesis models.
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研究種目 : 挑戦的研究 (萌芽)
研究期間 : 2018～2019
課題番号 : 18K19937
研究分野 : 組織工学
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