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KAKEN_18K17976seika.pdf
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:449.2 KB
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:Mar 5, 2021 |
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Total downloads since Mar 5, 2021 : 198
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Elucidating the anti-colitic mechanisms of rice bran supplementation via nutriomics
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Aw, WanPing
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アウ, ワンピン
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慶應義塾大学・政策・メディア研究科 (藤沢) ・特任助教
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Research team head
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科研費研究者番号 : 20736441
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2020
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科学研究費補助金研究成果報告書
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2019
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10％米ぬかを摂取したマウスが大腸炎発症による体重減少を抑制した．腸内細菌叢解析を行った結果，米ぬかの摂取によってClostridiaceaeの割合が高くなったことが明らかになった。無菌マウスへ米ぬかを摂取したマウスの糞便を経口投与して、大腸炎発症による体重減少を抑制した。米ぬかを摂取したマウスの便中のトリプトファン関連代謝物には有意義に変動した。
Our results suggest that colitic mice fed 10% RB supplemented diet had higher abundance of Clostridiaceae. Fecal microbiota transplantation from RB-fed mice suppressed colitis. This strongly suggests that RB suppresses colitis through gut microbiota modulation.The fecal metabolome profile was dynamically changed by RB intake. Enrichment analysis revealed that RB intervention enriched the tryptophan metabolism pathway. Our results revealed that RB improves colitis via gut environment modulation.
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研究種目 : 若手研究
研究期間 : 2018～2019
課題番号 : 18K17976
研究分野 : Nutriomics
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