| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_18K15933seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:219.7 KB
|
| Last updated |
:Mar 5, 2021 |
| Downloads |
: 192 |
Total downloads since Mar 5, 2021 : 192
|
|
| Release Date |
|
| Title |
| Title |
肺炎球菌性肺炎においてSectm1aが肺の感染免疫機構へ及ぼす作用の解明
|
| Kana |
ハイエン キュウキンセイ ハイエン ニ オイテ Sectm1a ガ ハイ ノ カンセン メンエキ キコウ エ オヨボス サヨウ ノ カイメイ
|
| Romanization |
Haien kyūkinsei haien ni oite Sectm1a ga hai no kansen men'eki kikō e oyobosu sayō no kaimei
|
|
| Other Title |
| Title |
The role of Sectm1a in the lung during penumococcal pneumonia
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
鎌田, 浩史
 |
| Kana |
カマタ, ヒロフミ
|
| Romanization |
Kamata, Hirofumi
|
| Affiliation |
慶應義塾大学・医学部 (信濃町) ・助教
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 60528545
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2020
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2019
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
肺炎球菌性肺炎は、近年の抗菌薬やワクチンの開発、普及にも関わらず、依然として致死的となりうる重大な呼吸器感染症であり、さらなる病態の解明、および、新たな治療戦略の構築が望まれていいます。今回の研究では、気道の上皮細胞が産生するSectm1aという物質が、肺内の免疫に重要な役割を果たすことを目的に、Sectm1aノックアウトマウスを作成し、実際にSectm1aの機能の一端を明らかにすることができました。
Pneumoncoccal pneumonia is one of the most prominent burdens of disease worldwide. Despite the development of antibiotics and vaccines, morbidity caused by pneumococcla pneumonia is still considerable. In this study, we aimed to clarify the role of epithelial cell-derived Sectm1a in the host defense during pneumonia by creating Sectm1a knock out mouse. Sectm1a KO mice allowed us to find undiscovered functions of Sectm1a in the lung during pneumonia.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 若手研究
研究期間 : 2018～2019
課題番号 : 18K15933
研究分野 : 呼吸器感染症学
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
|
| Index |
|
| Related to |
|
