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KAKEN_18K15251seika.pdf
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Download
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:80.4 KB
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:Mar 5, 2021 |
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Total downloads since Mar 5, 2021 : 264
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BRAF遺伝子変異陽性肺癌の臨床像、薬剤感受性に関する研究
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BRAF イデンシ ヘンイ ヨウセイ ハイガン ノ リンショウゾウ、ヤクザイ カンジュセイ ニ カンスル ケンキュウ
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BRAF idenshi hen'i yōsei haigan no rinshōzō, yakuzai kanjusei ni kansuru kenkyū
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Research of clinical profile and drug sensitivity of BRAF mutation-positive lung cancer
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池村, 辰之介
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イケムラ, シンノスケ
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Ikemura, Shinnosuke
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慶應義塾大学・医学部 (信濃町) ・助教
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Research team head
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科研費研究者番号 : 30445291
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2020
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科学研究費補助金研究成果報告書
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2019
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本邦最大規模の肺癌遺伝子変異検索システム LC-SCRUM-Japanのデータ解析を行った。非小細胞肺癌の34例 (非小細胞肺癌の約5%) にBRAF遺伝子変異が認められた。V600E 41%、それ以外は59%であった。患者背景としては、年齢中央値65歳、男 : 女 23例 (68％) : 11例 (32％) 、65％が喫煙者であった。腺癌91％、他、非小細胞肺癌 (NOS) 、多形癌であった。上記の各遺伝子変異のレトロウィルスベクターを作成し、各BRAF遺伝子変異を導入したBa/F細胞株を4種類を作成、BRAF阻害薬、MEK阻害薬とその併用による薬剤感受性試験を行い、データ解析中である。
We analyzed data from LC-SCRUM-Japan, the largest lung cancer gene mutation retrieval system in Japan. The BRAF gene mutation was found in 34 cases of non-small cell lung cancer (about 5% of non-small cell lung cancer), 41% in V600E and 59% in the others. Patient background was median age 65 years, male: 23 (68%) female: 11 (32%), and 65% were smokers. Adenocarcinoma (91%), non-small cell lung cancer (NOS), and polymorphic carcinoma. A retroviral vector for each of the above gene mutations was created, and four types of Ba/F cell lines carrying each BRAF gene mutation were created, and drug sensitivity tests with BRAF and MEK inhibitors and their combination were conducted, and data analysis is ongoing.
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研究種目 : 若手研究
研究期間 : 2018～2019
課題番号 : 18K15251
研究分野 : 腫瘍生物学関連
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