| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_18K15249seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:102.0 KB
|
| Last updated |
:Mar 5, 2021 |
| Downloads |
: 292 |
Total downloads since Mar 5, 2021 : 292
|
|
| Release Date |
|
| Title |
| Title |
骨肉腫に対するWntシグナルを標的とした治療法の検討
|
| Kana |
コツニクシュ ニ タイスル Wnt シグナル オ ヒョウテキ ト シタ チリョウホウ ノ ケントウ
|
| Romanization |
Kotsunikushu ni taisuru Wnt shigunaru o hyōteki to shita chiryōhō no kentō
|
|
| Other Title |
| Title |
Investigation of Wnt-signaling-targeted therapy for osteosarcoma
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
弘實, 透
|
| Kana |
ヒロザネ, トオル
|
| Romanization |
Hirozane, Tōru
|
| Affiliation |
慶應義塾大学・医学部 (信濃町) ・助教
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 70594539
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2020
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2019
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
本研究の目的は，骨肉腫に対するWntシグナル・TNIKを標的とした治療の作用機序と有効性を明らかにし，臨床の現場へと成果を還元する事である．申請者らは骨肉腫に対するWntシグナルを標的とした治療法を，Wntシグナルを正に制御するTNIKに着目し，研究を行った．本研究の結果から骨肉腫に対し，TNIKが治療標的となりうる事，その作用機序としてはがん幹細胞性の喪失，代謝変動を伴った脂肪細胞への分化転換誘導という新しい機序が示唆された．臨床応用へ向け，TNIK阻害剤のコンパニオンマーカーの検討などをさらに行っていく予定である．
The purpose of this study was to clarify the mechanism of action and efficacy of Wnt-signal-TNIK-targeted therapy for osteosarcoma, and to apply the results to clinical practice. We focused on TNIK, which positively regulates Wnt signaling, to study the treatment of osteosarcoma by targeting Wnt signaling. The results of this study suggested that TNIK could be a potential therapeutic target for osteosarcoma and suggested new mechanisms of action, such as loss of cancer stemness and induction of conversion to adipocytes with metabolic changes. We plan to further investigate companion markers of TNIK inhibitors for clinical application.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 若手研究
研究期間 : 2018～2019
課題番号 : 18K15249
研究分野 : 骨軟部腫瘍
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
|
| Index |
|
| Related to |
|
