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KAKEN_18K08951seika.pdf
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Download
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:94.6 KB
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:Nov 14, 2022 |
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Total downloads since Nov 14, 2022 : 176
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悪性脳腫瘍新生血管を治療標的としたペプチドワクチン療法の有効性予測因子の解明
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アクセイ ノウシュヨウ シンセイ ケッカン オ チリョウ ヒョウテキ トシタ ペプチド ワクチン リョウホウ ノ ユウコウセイ ヨソク インシ ノ カイメイ
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Akusei nōshuyō shinsei kekkan o chiryō hyōteki toshita pepuchido wakuchin ryōhō no yūkōsei yosoku inshi no kaimei
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Biomarkers for evaluation of clinical activity of VEGFR-targeted vaccines against malignant brain tumor patients
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植田, 良
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ウエダ, リョウ
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Ueda, Ryō
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team head
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科研費研究者番号 : 30317143
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戸田, 正博
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トダ, マサヒロ
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Toda, Masahiro
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慶應義塾大学・医学部 脳神経外科・教授
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Collaborator
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科研費研究者番号 : 20217508
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2021
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科学研究費補助金研究成果報告書
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2020
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本研究では、申請者らが実施している悪性脳腫瘍（悪性神経膠腫）、治療抵抗性の神経鞘腫等の新生血管を治療標的としたペプチドワクチン療法臨床試験被験者検体を用いて、免疫応答関連細胞・因子、また脳腫瘍血管新生および浸潤性関連因子について解析し、臨床的有効性との関連性を検証した。その結果、同ワクチン療法による臨床的有効性を認めた患者検体では、ワクチン療法後にVEGFR発現細胞反応性細胞傷害性T細胞の高頻度検出、血漿中のIL-8値の低下、腫瘍細胞におけるVEGFR高発現を認めており、これらの因子は、同ワクチン療法の治療効果評価や治療反応性予測に応用しうると考えられた。
Evaluation of immunological biomarkers may lead to better understanding of the critical immune response indicators that may help to predict clinical responses of cancer immunotherapy. We characterized status of immune cells, cytokines, chemokines, and other immunosuppressive molecules in refractory brain tumor patients who received vaccinations of VEGF receptor (VEGFR)-derived peptides. Peripheral blood samples from patients who demonstrated positive radiologic response or stable disease revealed superior VEGFR-specific CTL reactivity compared to samples from other patients with refractory brain tumors. Plasma IL-8 level was negatively correlated with overall survival. Furthermore, expression of VEGFR1 and VEGFR2 on tumor cells and immunosuppressive tumor-microenvironment were related to the therapeutic efficacy VEGFR-targeted vaccines. These data indicate that these parameters may be potential immune-biomarkers for evaluation of clinical activity of VEGFR-targeted vaccines.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2018～2020
課題番号 : 18K08951
研究分野 : 脳神経外科学
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| May 17, 2022 | | インデックス を変更 |
| Nov 14, 2022 | | Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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