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KAKEN_18H02582seika.pdf
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Download
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:138.5 KB
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| Last updated |
:May 17, 2022 |
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Total downloads since May 17, 2022 : 103
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| Title |
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幹細胞制御を目指した天然物基盤生死の天秤シグナルモジュレーターの創成
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| Kana |
カンサイボウ セイギョ オ メザシタ テンネンブツ キバン セイシ ノ テンビン シグナル モジュレーター ノ ソウセイ
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Kansaibō seigyo o mezashita tennenbutsu kiban seishi no tenbin shigunaru mojurētā no sōsei
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Development of signal modulators based on natural products for regulation of stem cells
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荒井, 緑
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アライ, ミドリ
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Arai, Midori
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慶應義塾大学・理工学部 (矢上) ・教授
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Research team head
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科研費研究者番号 : 40373261
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2021
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科学研究費補助金研究成果報告書
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2020
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| Abstract |
生体内には生命の維持に重要であるが，ひとたび変異等で異常亢進すると疾病の原因となる，生死の天秤とも呼べる重要なシグナル伝達が存在する．我々はこれらシグナルのモジュレーターを，独自のタンパク質および細胞アッセイを用いて活性天然物を亜熱帯植物および放線菌エキスライブラリーから探索した．また単離した化合物の全合成および誘導体合成と活性評価も行った．さらには微生物の休眠遺伝子活性化法として，微生物―動物細胞共培養法を開発した．
Although it is important for the maintenance of life in the living body, there is an important signal transduction that can be called a life-and-death balance, which causes illness once abnormally increased due to mutation. The search of bioactive natural products which can modulates these signal transductions have been conducted from subtropical plants and Actinomycetes extract library. The total synthesis of isolated compounds and derivatives. In addition, co-culture method of microorganism and animal cells was developed for activation method of cryptic genes.
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研究種目 : 基盤研究 (B) (一般)
研究期間 : 2018～2020
課題番号 : 18H02582
研究分野 : 天然物化学
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