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KAKEN_17K15249seika.pdf
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Title |
Title |
乳酸菌におけるシグナル配列非依存的なタンパク質の分泌機構の解明
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ニュウサンキン ニ オケル シグナル ハイレツ ヒイゾンテキナ タンパクシツ ノ ブンピツ キコウ ノ カイメイ
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Nyūsankin ni okeru shigunaru hairetsu hiizontekina tanpakushitsu no bunpitsu kikō no kaimei
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A typical signal sequence-independent export mechanism of elongation factor Tu in lactic acid bacteria
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西山, 啓太
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ニシヤマ, ケイタ
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Nishiyama, Keita
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team head
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科研費研究者番号 : 40756029
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向井, 孝夫
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ムカイ, タカオ
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Mukai, Takao
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北里大学・獣医学部
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Collaborator
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科研費研究者番号 : 20229917
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杉山, 真言
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スギヤマ, マコト
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Sugiyama, Makoto
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北里大学・獣医学部
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Collaborator
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科研費研究者番号 : 30648225
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2020
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科学研究費補助金研究成果報告書
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2019
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翻訳伸長因子 (EF-Tu) は,乳酸菌をはじめとする多くの腸内細菌において細胞外へ分泌され,細胞表層にとどまることで腸管定着因子としての機能を発揮するタンパク質である。しかし,これまでEF-Tuの細胞外への分泌機構はほとんど不明であった。本研究では,EF-TuのC末端に保存される特定のアミノ酸依存的に膜輸送経路により分泌される,EF-Tuの新たな分泌機構を明らかにした。
Several cytoplasmic proteins such as elongation factor Tu (EF-Tu), which lack a typical N-terminal export signal sequence, have been found to be localized outside the cell in several Lactobacillus strains. EF-Tu often exert additional functions as a bacterial adhesion factor. However, the mechanism underlying the N-terminal typical signal sequence-independent export of these cytoplasmic proteins is largely unknown. Here we identified the secretion of EF-Tu depends on the C-terminal sequence containing certain hydrophobic amino acid residues and that the sequence contributes to the membrane export processes. This study improves our understanding of the Lactobacillus colonization strategy in the intestinal environment.
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研究種目 : 若手研究 (B)
研究期間 : 2017~2019
課題番号 : 17K15249
研究分野 : 応用微生物学
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