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KAKEN_17K11158seika.pdf
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前立腺癌における不均一性と可塑性を標的とした新規バイオマーカー探索と新規治療戦略
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ゼンリツセンガン ニ オケル フキンイツセイ ト カソセイ オ ヒョウテキ ト シタ シンキ バイオマーカー タンサク ト シンキ チリョウ センリャク
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Zenritsusengan ni okeru fukin'itsusei to kasosei o hyōteki to shita shinki baiomākā tansaku to shinki chiryō senryaku
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Search for biomarkers and novel therapeutic strategies targeting heterogeneity and plasticity in prostate cancer
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小坂, 威雄
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コサカ, タケオ
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Kosaka, Takeo
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慶應義塾大学・医学部 (信濃町) ・講師
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Research team head
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科研費研究者番号 : 30445407
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本郷, 周
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ホンゴウ, ヒロシ
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Hongō, Hiroshi
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慶應義塾大学・医学部 (信濃町) ・特任助教
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Research team member
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科研費研究者番号 : 10626675
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2020
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科学研究費補助金研究成果報告書
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2019
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リキッドバイオプシー (血液循環腫瘍細胞、cfDNA) による去勢抵抗性前立腺癌患者の個別化分子モニタリングのための検体採取方法の確立、リキッドバイオプシー検体と生検検体のNGS解析による統合的解析、抗がん剤耐性ヒトCRPC細胞株のオミックスデータを応用した新規薬剤スクリーニングを実施した。ラベルフリーによるCTCの回収率向上とシングルRNAシーケンス解析に成功、バイオマーカーとしての意義を見出した。転移性前立腺がん患者のcfDNAと同時期に採取した生検検体をNGS解析し共通した遺伝子変異を同定した。カバジタキセル耐性をリプログラミングする新規シーズを同定した。
Castration-resistant prostate cancer (CRPC) is heterogeneous and plastic.The establishment of new treatment strategies for refractory prostate cancer is an urgent task. Establishment of sample collection method for patient-specific molecular monitoring by liquid biopsy (blood circulation tumor cells, cfDNA), Integrated analysis of liquid biopsy specimens and biopsy specimens by NGS analysis,We conducted a new drug screening using omics data of anti-cancer drug resistant human CRPC cell line. We succeeded in improving the recovery rate of CTC by label-free and single RNA sequence analysis, We identified its significance as a biomarker. NGS analysis was performed on biopsy samples taken at the same time as the cfDNA of patients with metastatic prostate cancer to identify common gene mutations.We have identified novel seeds that reprogram cabazitaxel resistance.
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研究種目 : 基盤研究 (C) (一般)
研究期間 : 2017～2019
課題番号 : 17K11158
研究分野 : 前立腺癌
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