| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_16K19982seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:135.5 KB
|
| Last updated |
:Oct 31, 2019 |
| Downloads |
: 187 |
Total downloads since Oct 31, 2019 : 187
|
|
| Release Date |
|
| Title |
| Title |
肺悪性腫瘍に対する凍結融解壊死療法と免疫賦活剤の併用療法の開発
|
| Kana |
ハイ アクセイ シュヨウ ニ タイスル トウケツ ユウカイ エシ リョウホウ ト メンエキ フカツザイ ノ ヘイヨウ リョウホウ ノ カイハツ
|
| Romanization |
Hai akusei shuyō ni taisuru tōketsu yūkai eshi ryōhō to men'eki fukatsuzai no heiyō ryōhō no kaihatsu
|
|
| Other Title |
| Title |
Development of the combination therapy with cryoablation and immune checkpoint inhibitor for lung cancer
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
加勢田, 馨
 |
| Kana |
カセダ, カオル
|
| Romanization |
Kaseda, Kaoru
|
| Affiliation |
慶應義塾大学・医学部 (信濃町)・助教
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 70624435
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2019
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2018
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
ルイス肺癌細胞を大腿皮下に注入したマウスモデルを用いた。約1.5cm大に成長した腫瘍に対して凍結融解壊死療法あるいは凍結免疫療法を施行し、Day60にマウスを犠牲死させた後、凍結腫瘍の病理組織学的評価を施行した。結果として、凍結免疫療法は凍結融解壊死療法に比較し、より高い局所制御能を有することが示唆された。また、免疫チェックポイント阻害薬の投与経路としては、腫瘍局所投与の方がより局所制御能を高める結果であった。一方、投与する免疫チェックポイント阻害薬ごとの抗腫瘍効果に差異は認めなかった。
Cryotherapy and cryoimmunotherapy were performed to 1.5cm femoral tumor that originated from Lewis Lung Cancer cell. Histologically, the area of nonviable tumor was significantly increased in size in cryoimmunotherapy group than cryotherapy group (Average: 88% vs 73%). Our data suggest that cryoimmunotherapy is superior than cryotherapy in local control and the most effective route is local administration. On the other hand, there was no difference in the effectiveness of local control between these three immune checkpoint inhibitors.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 若手研究(B)
研究期間 : 2016～2018
課題番号 : 16K19982
研究分野 : 呼吸器外科
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
|
| Index |
|
| Related to |
|
