| Item Type |
Article |
| ID |
|
| Preview |
| Image |
|
| Caption |
|
|
| Full text |
KAKEN_16K11379seika.pdf
| Type |
:application/pdf |
Download
|
| Size |
:79.1 KB
|
| Last updated |
:Nov 14, 2022 |
| Downloads |
: 191 |
Total downloads since Nov 14, 2022 : 191
|
|
| Release Date |
|
| Title |
| Title |
自己細胞由来誘導性血小板成長因子剤によるパーソナル治療
|
| Kana |
ジコ サイボウ ユライ ユウドウセイ ケッショウバン セイチョウ インシザイ ニ ヨル パーソナル チリョウ
|
| Romanization |
Jiko saibō yurai yūdōsei kesshōban seichō inshizai ni yoru pāsonaru chiryō
|
|
| Other Title |
| Title |
The autologus cure by manufactureing platelets from a human cell line
|
| Kana |
|
| Romanization |
|
|
| Creator |
| Name |
矢澤, 真樹
 |
| Kana |
ヤザワ, マサキ
|
| Romanization |
Yazawa, Masaki
|
| Affiliation |
慶應義塾大学・医学部 (信濃町) ・講師
|
| Affiliation (Translated) |
|
| Role |
Research team head
|
| Link |
科研費研究者番号 : 60327567
|
| Name |
森, 泰昌
|
| Kana |
モリ, タイスケ
|
| Romanization |
Mori, Taisuke
|
| Affiliation |
国立研究開発法人国立がん研究センター・中央病院・医員
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
科研費研究者番号 : 00296708
|
| Name |
松原, 由美子
|
| Kana |
マツバラ, ユミコ
|
| Romanization |
Matsubara Yumiko
|
| Affiliation |
慶應義塾大学・医学部 (信濃町) ・特任准教授
|
| Affiliation (Translated) |
|
| Role |
Research team member
|
| Link |
科研費研究者番号 : 70365427
|
|
| Edition |
|
| Place |
|
| Publisher |
|
| Date |
| Issued (from:yyyy) |
2020
|
| Issued (to:yyyy) |
|
| Created (yyyy-mm-dd) |
|
| Updated (yyyy-mm-dd) |
|
| Captured (yyyy-mm-dd) |
|
|
| Physical description |
|
| Source Title |
| Name |
科学研究費補助金研究成果報告書
|
| Name (Translated) |
|
| Volume |
|
| Issue |
|
| Year |
2019
|
| Month |
|
| Start page |
|
| End page |
|
|
| ISSN |
|
| ISBN |
|
| DOI |
|
| URI |
|
| JaLCDOI |
|
| NII Article ID |
|
| Ichushi ID |
|
| Other ID |
|
| Doctoral dissertation |
| Dissertation Number |
|
| Date of granted |
|
| Degree name |
|
| Degree grantor |
|
|
| Abstract |
血小板には各種成長因子が多く含まれており、止血・凝固作用後の傷において、これらの成長因子が複合的に働き、創部の創傷治癒過程で大きな寄与をしていることが分かってきた。そこで自己細胞由来誘導性血小板を作製してパーソナル治療剤の開発に繋げる本研究を行った。自己細胞由来誘導性血小板は、創傷治癒に有効性を示すサイトカインを含有し、刺激による活性化能を有していた。免疫不全創傷治癒モデルマウスを用いてbFGFと比較した検討を行った。活性化した自己細胞由来誘導性血小板は、bFGF濃度が低くても、様々なサイトカインや成長因子の相互作用により、bFGF単体より創傷治癒効果が高いことが確認できた。
Platelets are released from mature megakaryocytes and have an essential role in hemostatic plug formation. Recently, a line of evidence supports the clinical application of platelets to accelerate wound healing. However, it is difficult to use peripheral platelets for wide-range wound. Pre-adipocyte-derived platelets have the ability of activation and contain cytokines in relation to wound healing. We examined the effect of pre-adipocyte-derived platelets on wound healing of immunodeficient NOG mouse with full-thickness excisional wound in comparison to bFGF. While bFGF concentration in supernatant of activated platelets was low, they released various cytokines and growth factors related tissue repair and showed more beneficial effects on wound healing than bFGF.
|
|
| Table of contents |
|
| Keyword |
|
| NDC |
|
| Note |
研究種目 : 基盤研究 (C) (一般)
研究期間 : 2016～2019
課題番号 : 16K11379
研究分野 : 形成外科
|
|
| Language |
|
| Type of resource |
|
| Genre |
|
| Text version |
|
| Related DOI |
|
| Access conditions |
|
| Last modified date |
|
| Creation date |
|
| Registerd by |
|
| History |
| Mar 5, 2021 | | インデックス を変更 |
| Nov 14, 2022 | | Creator 著者ID,Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
|
|
| Index |
|
| Related to |
|
