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KAKEN_16K10770seika.pdf
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Download
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:81.6 KB
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:Oct 31, 2019 |
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Total downloads since Oct 31, 2019 : 391
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新規癌抗原分子KIF20Aの神経膠腫における発現・機能解析
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シンキガン コウゲン ブンシ KIF20A ノ シンケイ コウシュ ニ オケル ハツゲン・キノウ カイセキ
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Shinkigan kōgen bunshi KIF20A no shinkei kōshu ni okeru hatsugen kinō kaiseki
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Expression and function analysis of novel cancer antigen molecule KIF20A in gliomas
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三輪, 点
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ミワ, トモル
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Miwa, Tomoru
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慶應義塾大学・医学部 (信濃町)・講師
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Research team head
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科研費研究者番号 : 20365282
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2019
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科学研究費補助金研究成果報告書
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2018
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発現解析の結果、正常脳組織や他の癌腫細胞株と比較して新規癌抗原KIF20Aは神経膠腫細胞株・神経膠腫患者組織において強く発現していることが確認できた。次に細胞周期に与える影響や細胞死誘導の有無を解析した結果、ダウンレギュレーションしたKIF20Aは神経膠腫において細胞質分裂障害による細胞増殖抑制をきたしていることが確認できた。それらを踏まえ、担癌 (神経膠腫)マウスモデルにおける抗腫瘍効果の評価を行い、免疫組織学的解析によるKIF20Aの発現、また脳腫瘍増殖能・浸潤能への影響が確認された。
We demonstrated that the tumor-associated antigen, KIF20A, was highly expressed in gliomas, but was rarely expressed in adult normal tissues. Down-regulation of KIF20A induced glioma cell growth suppression due to the failure of cytokinesis, and therefore, KIF20A has an essential role in glioma cell proliferation. Although immunological investigations are needed before KIF20A is investigated clinically, our findings indicate that KIF20A may be a promising molecular target for glioma immunotherapy.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2016～2018
課題番号 : 16K10770
研究分野 : 脳腫瘍
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