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KAKEN_15K20111seika.pdf
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Download
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:379.0 KB
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| Last updated |
:Sep 21, 2017 |
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Total downloads since Sep 21, 2017 : 227
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| Title |
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GEP100-Arf6-AMAP1経路を介した新規尿路上皮間葉転換制御機構の解明
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GEP100-Arf6-AMAP1 ケイロ オ カイシタ シンキ ニョウロ ジョウヒ カンヨウ テンカン セイギョ キコウ ノ カイメイ
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GEP100-Arf6-AMAP1 keiro o kaishita shinki nyoro johi kanyo tenkan seigyo kiko no kaimei
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Epithelial to mesenchymal transition thorough GEP100-Arf6-AMAP1 pathway in urothelial cancer
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大門, 達明
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ダイモン, タツアキ
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Daimon, Tatsuaki
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慶應義塾大学・医学部・助教
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Research team head
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科研費研究者番号 : 40573275
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菊地, 栄次
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キクチ, エイジ
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Kikuchi, Eiji
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慶應義塾大学・医学部・講師
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Research team member
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科研費研究者番号 : 10286552
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小坂, 威雄
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コサカ, タケオ
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Kosaka, Takeo
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慶應義塾大学・医学部・講師
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Research team member
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科研費研究者番号 : 30445407
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大家, 基嗣
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オオヤ, モトツグ
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Oya, Mototsugu
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慶應義塾大学・医学部・教授
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Research team member
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科研費研究者番号 : 00213885
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佐邊, 壽孝
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サベ, ヒサタカ
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Sabe, Hisataka
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北海道大学・大学院医学研究科・教授
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Research team member
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科研費研究者番号 : 40187282
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2017
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科学研究費補助金研究成果報告書
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2016
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| Abstract |
尿路上皮癌細胞株T24, UMUC-3におけるEPB4.1L5の発現をwestern blotting並びに免疫蛍光染色で検討した。EPB4.1L5の発現を認めた。腎盂尿管全摘除術を施行した165例を対象とした(Ta-4N0-1M0)臨床検体のホルマリン固定パラフィン包埋組織切片を抗EPB4.1L5抗体を用い免疫組織化学染色を行った。EPB4.1L5の発現をスコアと臨床病理学的所見との関連を, 統計学的に解析を行った。EPB4.1L5の強発現は臨床病期, グレード, 壁内脈管浸潤と有意な相関を認めた。また強発現群においては弱発現群に比し有意に無再発生存率, 癌特異的生存率が低かった。
We examined EPB4.1L5 expression in urothelial cancer cells, T24 and UMUC-3 by western blotting and immunofluorescence staining. We found the EPB4.1L5 expressin in those cell lines. Retrospective analysis of the clinical records of 165 patients with UTUC (Ta-4N0M0) subjected to radical nephroureterectomy and immunohistochemical examination of EPB4.1L5 expression in those tissues. The score of EPB4.1L5 significantly correlated with tumor grade, pathological T stage, and lymphovascular invasion. The 5-year Kaplan-Meier recurrence-free survival and cancer-specific survival rates were 54.1% and 59.5% in patients with high EPB4.1L5 expression, compared with 81.6% and 87.2%,(all p＜0.001) in their counterparts. Multivariate analyses revealed that high expression of EPB4.1L5 was one of the independent prognostic factors for tumor recurrence and cancer specific survival.
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研究種目 : 若手研究(B)
研究期間 : 2015～2016
課題番号 : 15K20111
研究分野 : 泌尿器科学
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