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KAKEN_15K10903seika.pdf
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Download
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:154.9 KB
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:Apr 12, 2024 |
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Total downloads since Apr 12, 2024 : 202
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疾患iPS研究に基づく網膜色素変性症に対する新規神経保護治療薬の開発に向けた研究
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シッカン iPS ケンキュウ ニ モトズク モウマク シキソ ヘンセイショウ ニ タイスル シンキ シンケイ ホゴ チリョウヤク ノ カイハツ ニ ムケタ ケンキュウ
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Shikkan iPS kenkyū ni motozuku mōmaku shikiso henseishō ni taisuru shinki shinkei hogo chiryōyaku no kaihatsu ni muketa kenkyū
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Development of a neuroprotective therapy for retinitis pigmentosa based on the iPS research
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小澤, 洋子
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オザワ, ヨウコ
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Ozawa, Yoko
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慶應義塾大学・医学部(信濃町)・専任講師
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Research team head
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科研費研究者番号 : 90265885
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川島, 弘彦
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カワシマ, ヒロヒコ
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Kawashima, Hirohiko
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Research team member
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長田, 秀斗
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オサダ, ヒデト
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Osada, Hideto
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Research team member
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2018
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科学研究費補助金研究成果報告書
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2017
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研究代表者らはこれまでに, 遺伝子変異により発症する網膜色素変性症の患者体細胞由来の人工多能性細胞(induced-pluripotent stem cell ; iPS細胞)を用いて網膜細胞を誘導・培養し, 神経保護治療法薬剤の開発に向けた病態メカニズムの解析(疾患iPS研究) を行い報告した。
本研究では, 疾患iPS研究の培養において有効性があった薬剤を, 網膜色素変性症モデルマウス(ロドプシンP23Hノックインマウス)に投与して, 生体内で網膜神経細胞の保護 (細胞死抑制) 効果を解析した。
We have previously developed induced-pluripotent stem cell (iPSC) lines from somatic cells of a patient with retinitis pigmentosa, which is a hereditary disease caused by gene mutation. The iPS cells were differentiated into retinal cells to reveal the mechanism of the disease in vitro, and the study proposed candidate therapeutic drugs for neuroprotection. In the current study, we treated the mouse model of retinitis pigmentosa (P23H rhodopsin knock-in mice) with one of the candidate drugs to analyze the protective effects in vivo.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2015～2017
課題番号 : 15K10903
研究分野 : 眼科学
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| Nov 12, 2018 | | インデックス を変更 |
| Apr 12, 2024 | | Creator 著者ID,Creator Name,Creator Kana,Creator Romanization,Creator Affiliation,Creator Affiliation (Translated),Creator Role,Creator Link,Abstract 内容,Note 注記 を変更 |
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