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KAKEN_15K08595seika.pdf
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Download
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:84.2 KB
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| Last updated |
:Nov 12, 2018 |
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Total downloads since Nov 12, 2018 : 230
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| Title |
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胎盤における母体環境ストレス緩和初動因子の機能発現制御
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タイバン ニ オケル ボタイ カンキョウ ストレス カンワ ショドウ インシ ノ キノウ ハツゲン セイギョ
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Taiban ni okeru botai kankyō sutoresu kanwa shodō inshi no kinō hatsugen seigyo
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Functional expression of sensing factors against maternal osmotic stress in the placenta
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西村, 友宏
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ニシムラ, トモヒロ
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Nishimura, Tomohiro
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慶應義塾大学・薬学部・准教授
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Research team head
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科研費研究者番号 : 40453518
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登美, 斉俊
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トミ, マサトシ
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Tomi, Masatoshi
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慶應義塾大学・薬学部・教授
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Research team member
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科研費研究者番号 : 30334717
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2018
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科学研究費補助金研究成果報告書
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2017
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胎盤は母体および胎児間の物質輸送を担う臓器であるが, 母体における循環血中の成分変動の影響を緩和し, 安定的に機能する作用をもつ。胎盤において, 胎児が必要とするアミノ酸の一部はシステムAと呼ばれるアミノ酸輸送機構を介して母体から胎児に供給される。本研究では, このアミノ酸輸送システムAの一部の分子は, 母体循環血成分の変動に対し速やかに反応し, 特に高い浸透圧ストレス負荷時には他の機能分子に先駆けて発現が増加すること, およびその発現変動機構の一部を明らかにした。
Placenta is an interface between mother and fetus and it has a role of nutrients transfer. The placenta has the function mitigating the osmotic stress exposed from maternal blood. Part of amino acid is transferred via amino acid transport system A from mother to fetus in the placenta. In this study, we clarified that expression of the system A molecule can be more quickly increased in response to the osmotic stress than other molecules and we investigated how the system A molecules is induced by hypertonic stress.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2015～2017
課題番号 : 15K08595
研究分野 : 生物薬剤学
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