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KAKEN_15K06746seika.pdf
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Title |
Title |
Reelinシグナルを伝えるDab1の翻訳後修飾による神経細胞移動制御機構の解明
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Reelin シグナル オ ツタエル Dab1 ノ ホンヤクゴ シュウショク ニ ヨル シンケイ サイボウ イドウ セイギョ キコウ ノ カイメイ
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Reelin shigunaru o tsutaeru Dab1 no honyakugo shūshoku ni yoru shinkei saibō idō seigyo kikō no kaimei
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Analysis of the neuronal migration regulation mechanism by post-translational modification of Dab1
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本田, 岳夫
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ホンダ, タカオ
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Honda, Takao
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慶應義塾大学・医学部(信濃町)・講師
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Research team head
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科研費研究者番号 : 30365225
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2018
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科学研究費補助金研究成果報告書
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2017
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Dab1は大脳新皮質神経細胞の移動や樹状突起形成に必須の役割を持つ細胞内タンパク質である。これまで, Dab1のチロシン残基の翻訳後修飾がReelinシグナルに必須の役割を持つことが示されてきたが, それ以外のアミノ酸残基の役割についてはほとんど検討されてこなかった。研究代表者らはDab1の一次配列中に, 種間で高度に保存された翻訳後修飾を受ける可能性のあるアミノ酸配列を見出し, Dab1の機能制御の可能性を検討した。その結果, 神経細胞移動を制御する可能性のある翻訳後修飾部位を新たに同定した。
Dab1 is an intracellular protein that has an essential role in neuronal migration of cerebral cortical neurons and formation of their dendrites. So far, it has been shown that posttranslational modification of tyrosine residues of Dab1 has essential roles in Reelin signaling pathway, however it remains unknown whether other amino acid residues which might be post-translationally modified are involved in Reelin-Dab1 signaling pathway. We found that some amino acids sequences are highly conserved among different species in the primary sequence of Dab1, and thus hypothesized that those sequences might be post-translationally modified. Thus, we examined the possibility of functional control of Dab1 by those amino acids. As a result, we found that the putative posttranslational modification sites are required for the correct neuronal migration.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2015~2017
課題番号 : 15K06746
研究分野 : 神経発生学
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