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KAKEN_15K06745seika.pdf
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Title |
Title |
大脳新皮質層構造形成の礎となる脳表層下における神経細胞集積機構
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Kana |
ダイノウ シンヒシツソウ コウゾウ ケイセイ ノ イシズエ ト ナル ノウ ヒョウソウカ ニ オケル シンケイ サイボウ シュウセキ キコウ
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Dainō shinhishitsusō kōzō keisei no ishizue to naru nō hyōsōka ni okeru shinkei saibō shūseki kikō
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Molecular mechanism of Reelin-induced neuronal aggregation in the developing mouse cerebral cortex
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林, 周宏
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ハヤシ, カネヒロ
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Hayashi, Kanehiro
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慶應義塾大学・医学部(信濃町)・講師
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Research team head
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科研費研究者番号 : 60373354
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井上, 聖香
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イノウエ, セイカ
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Inoue, Seika
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Research team member
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2018
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科学研究費補助金研究成果報告書
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2017
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哺乳類発生期の大脳新皮質は, 興奮性ニューロンによって形成される6層構造を有しており, 脳の高次活動を可能にしている。本研究は, 分泌タンパク質Reelinによる層構造形成機構を解明することを目的として遂行した。
本研究で, Reelinにより誘導される神経細胞凝集塊形成がN-cadherinによる接着力の亢進を媒介して起こること, および, このN-cadherinを介した細胞間接着増強が一過的であることを見出した。また, Nck2, p120catenin両分子が, このReelinによるN-cadherin依存性細胞接着制御機構に関与することも明らかにした。
本研究の成果は国内外の学会および国際誌で発表した。
The mammalian neocortex has the six layered structure organized by excitatory neurons, which enables higher brain functions. A secretary molecule 'Reelin' is essential for the layer formation, but the molecular mechanism based on Reelin for the layer formation remains to be elucidated. The purpose of the current project is to clarify cellular and molecular mechanisms to form the layered structure based on Reelin during cortical development. In this study, we found that Reelin-inducible neuronal aggregate was mediated by N-cadherin-based cellular adhesion and that this promotion of cellular adhesion by Reelin was in a transient manner. Moreover, we revealed p120 catenin and Nck were involved in this N-cadherin-based cellular adhesion.
These results were presented in several scientific meetings and published in an international journal.
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研究種目 : 基盤研究(C)(一般)
研究期間 : 2015~2017
課題番号 : 15K06745
研究分野 : 神経発生
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